Enhancing the antitumor effect of methotrexate in intro and in vivo by a novel targeted single-walled carbon nanohorn-based drug delivery system

Wang, Ran; Cui, Hongjing; Wang, Junling; Li, Nannan; Zhao, Qian; Zhou, Ying; Lv, Zhiyi; Zhong, Wenying

doi:10.1039/c6ra06667d

Cited by 26 publications

(9 citation statements)

References 48 publications

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“…SWCNHs that possess similar structures as those of CNTs also allow the multifunctionalization of target ligands and drug molecules on both the inner and outer tube walls. − After oxidation, the hole of the SWCNHs can be opened and filled with functional carboxyl groups at the edges that provide covalent binding sites for different drug molecules. The intrinsic cytotoxicity of SWCNHs is found to be lower than that of the CNTs due to the less-contaminated production reaction in the absence of metal catalysts.…”

Section: Nanocarbons For In Vitro Applications: Sensing Imaging and D...mentioning

confidence: 99%

Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery

et al. 2019

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Nanocarbons with different dimensions (e.g., 0D fullerenes and carbon nanodots, 1D carbon nanotubes and graphene nanoribbons, 2D graphene and graphene oxides, and 3D nanodiamonds) have attracted enormous interest for applications ranging from electronics, optoelectronics, and photovoltaics to sensing, bioimaging, and therapeutics due to their unique physical and chemical properties. Among them, nanocarbon-based theranostics (i.e., therapeutics and diagnostics) is one of the most intensively studied applications, as these nanocarbon materials serve as excellent biosensors, versatile drug/gene carriers for specific targeting in vivo, effective photothermal nanoagents for cancer therapy, and promising fluorescent nanolabels for cell and tissue imaging. This review provides a systematic overview of the latest theranostic applications of nanocarbon materials with a comprehensive comparison of the characteristics of different nanocarbon materials and their influences on theranostic applications. We first introduce the different carbon allotropes that can be used for theranostic applications with their respective preparation and surface functionalization approaches as well as their physical and chemical properties. Theranostic applications are described separately for both in vitro and in vivo systems by highlighting the protocols and the studied biosystems, followed by the toxicity and biodegradability implications. Finally, this review outlines the design considerations for nanocarbon materials as the key unifying themes that will serve as a foundational first principle for researchers to study, investigate, and generate effective, biocompatible, and nontoxic nanocarbon materials-based models for cancer theranostics applications. Finally, we summarize the review with an outlook on the challenges and novel theranostic protocols using nanocarbon materials for hard-to-treat cancers and other diseases. This review intends to present a comprehensive guideline for researchers in nanotechnology and biomedicine on the selection strategy of nanocarbon materials according to their specific requirements. CONTENTSRelated Molecules by Different Nano-54 carbon Materials W 55 2.2. Nanocarbons for in Vitro Bioimaging AD 56 2.2.1. In Vitro Imaging by Graphene AD 57 2.2.2. In Vitro Imaging by Carbon Nanotubes AF 58 2.2.3. In Vitro Imaging by Fullerenes AH 59 2.2.4. In Vitro Imaging by Carbon Nanohorns AI 60 2.2.5. In Vitro Imaging by Nanodiamonds AJ

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Section: Nanocarbons For In Vitro Applications: Sensing Imaging and D...mentioning

confidence: 99%

Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery

et al. 2019

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“…It has been established that cancer is spread worldwide and responsible for about 15% of all deaths [20]. Many drugs with anticancer and antiviral activities have been developed [21], such as zidovudine (AZT) [22], zalcitabine (DDC) [23], brivudine (BVDU) [24], and methotrexate (MTX) [25]. 4-Deazatoxaflavin (1,6-dimethyl-1,5,6,7-tetrahydropyrimido[4,5- c ]pyridazine-5,7-dione) binds to herring sperm DNA and inhibits growth of Pseudomonas 568 [21,26].…”

Section: Introductionmentioning

confidence: 99%

A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution

El‐Kalyoubi

Agili

2016

Molecules

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Abstract:A variety of different compounds of fused uracils were prepared simply by the heating of 6-hydrazinyl-1-methyl-, 6-hydrazinyl-1-propyl-, or 6-hydrazinyl-1,3-dipropyluracil under reflux with ninhydrin, isatin, benzylidene malononitrile, benzylylidene ethyl cyanoacetate, benzil, and phenacyl bromide derivatives. The newly synthesized compounds were completely screened for antimicrobial and antitumor activity.

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“…They tend to form spherical aggregates larger than 100 nm. Carbon nanohorms have been explored as a potential anticancer agent for the delivery of antineoplastic drugs known from clinical practice, including cisplatin and dexamethasone [ 122 ].…”

Section: Carbon-based Nanomaterials With Antitumor Activitiesmentioning

confidence: 99%

Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates

et al. 2022

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Melanoma is an aggressive skin cancer that affects approximately 140,000 people worldwide each year, with a high fatality rate. Available treatment modalities show limited efficacy in more severe cases. Hence, the search for new treatment modalities, including immunotherapies, for curing, mitigating, and/or preventing cancer is important and urgently needed. Carbon nanoparticles associated with some plant materials, such as Aloe vera, have shown appealing antineoplastic activity, derived mainly from the compounds aloin, aloe-emodin, barbaloin acemannan, and octapeptide, thus representing new possibilities as antitumor agents. This systematic review aims to arouse interest and present the possibilities of using Aloe vera combined with carbon-based nanomaterials as an antineoplastic agent in the treatment and prevention of melanoma. Limitations and advances in melanoma treatment using functionalized carbon nanomaterials are discussed here. Moreover, this review provides the basis for further studies designed to fully explore the potential of carbon nanomaterials associated with Aloe vera in the treatment of various cancers, with a focus on melanoma.

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Enhancing the antitumor effect of methotrexate in intro and in vivo by a novel targeted single-walled carbon nanohorn-based drug delivery system

Abstract: The present research reports a smart multifunctional oxidized single-wall carbon nanohorns (oxSWNHs) drug delivery system (DDS) which could enhance the anti-tumor effect of methotrexate (MTX).

Cited by 26 publications

References 48 publications

Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery

Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery

A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution

Effects of Carbon Nanomaterials and Aloe vera on Melanomas—Where Are We? Recent Updates

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