Enhancing the biological properties of zinc complexes with bis(indolyl)methane groups: Synthesis, characterization, DNA interaction, and biocide activity

Synthesis of Zn(ii) coordination complexes, their molecular design and docking with SARS-CoV-2 RBD protein and Omicron spike protein

“…Zinc has long been recognized as a trace element for the proper functioning of numerous proteins/enzymes in cells, and it has long been known that zinc is an important co-factor of cellular proteins and many viral proteins involved in anti-oxidant defence and protein expression. 15,16 The dicationic redox inactive Zn 2+ has a d 10 configuration, is diamagnetic, is a strong Lewis acid, can stabilize different coordination geometries, and is susceptible to the fast exchange of ligands. Many computational and structural studies have evidenced the significance of Zn(II) complexes and reported they show a variety of geometries and coordination numbers of chelating ligands characterized by different hapticities and donor atoms.…”