Enhancing the efficacy of fluconazole against Leishmania major: Formulation and evaluation of FLZ-nanoemulsions for topical delivery

Nahanji, Manizheh Kashi; Mahboobian, Mohammad Mehdi; Harchegani, Amir Larki; Mohebali, Mehdi; Fallah, Mohammad; Nourian, Alireza; Motavallihaghi, Seyedmousa; Maghsood, Amir Hossein

doi:10.1016/j.biopha.2024.117109

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.117109

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Enhancing the efficacy of fluconazole against Leishmania major: Formulation and evaluation of FLZ-nanoemulsions for topical delivery

Manizheh Kashi Nahanji,

Mohammad Mehdi Mahboobian,

Amir Larki Harchegani

et al.

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Classical and innovative drugs for the treatment of Leishmania infections

Mota,

Guedes,

Jain

et al. 2024

Discov Public Health

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Although among the six most common parasitic diseases, leishmaniasis is considered a neglected disease, being recognised as a serious public health burden worldwide. This fact impairs technological advancements and investments in innovative therapeutic approaches, so that commonly available drugs are still associated with low therapeutic rates and significant side effects. Pentavalent antimonials, such as Pentostan® and Glucantime®, were established as chemotherapeutic agents since the 1940s, being the first line of treatment for leishmaniasis; however, 60% of cases of leishmaniasis are resistant to pentavalent antimonials. Thus, the search for more effective therapies and new therapeutic agents with potential leishmanicidal activity is still in-demand. In this review, an overview about the disease and its pathophysiology is given, discussing the current state-of-the-art of the standard treatments and new alternatives based on drug delivery approaches, enhancing the need for more effective pharmaceutical treatments.

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Classical and innovative drugs for the treatment of Leishmania infections

Mota,

Guedes,

Jain

et al. 2024

Discov Public Health

View full text Add to dashboard Cite

show abstract

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Enhancing the efficacy of fluconazole against Leishmania major: Formulation and evaluation of FLZ-nanoemulsions for topical delivery

Cited by 1 publication

References 41 publications

Classical and innovative drugs for the treatment of Leishmania infections

Classical and innovative drugs for the treatment of Leishmania infections

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