Enhancing the efficiency of disc membrane chromatography modules by using a flow directing layer

Madadkar, Pedram; Mahansaria, Riddhi; Mukherjee, Joydeep; Ghosh, Raja

doi:10.1016/j.memsci.2019.03.026

Cited by 7 publications

(3 citation statements)

References 27 publications

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Section: Membrane Equipmentmentioning

confidence: 99%

“…Madadkar et al [ 92 ] proposed to set a flow-directing layer on the front or back of the disc. Re-directing the liquid flow could solve the problem of the long solute stay time in the disc membrane chromatography and thus improve the separation efficiency [ 92 ]. Chen et al [ 89 ] reported an annular-flow hollow-fiber membrane chromatography installation designed from the perspective of fluid; this device solves poor fluid dynamics and invalid volume.…”

Section: Membrane Equipmentmentioning

confidence: 99%

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Recent development and application of membrane chromatography

Chen

Cong

et al. 2022

Anal Bioanal Chem

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Membrane chromatography is mainly used for the separation and purification of proteins and biological macromolecules in the downstream processing process, also applications in sewage disposal. Membrane chromatography is recognized as an effective alternative to column chromatography because it significantly improves chromatography from affinity, hydrophobicity, and ion exchange; the development status of membrane chromatography in membrane matrix and membrane equipment is thoroughly discussed, and the applications of protein capture and intermediate purification, virus, monoclonal antibody purification, water treatment, and others are summarized. This review will provide value for the exploration and potential application of membrane chromatography. Graphical abstract

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Section: Membrane Equipmentmentioning

confidence: 99%

Section: Membrane Equipmentmentioning

confidence: 99%

Recent development and application of membrane chromatography

Chen

Cong

et al. 2022

Anal Bioanal Chem

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“…Most of the commercial axial flow stacked-disc membrane modules have tapered inlet and a porous mesh-like material adjacent to the membrane for the equal distribution of flow and the tapered outlet [60,70]. Some pioneering researchers have introduced a flow directing layer (FDL) within the axial flow stacked-disc membrane module either in the front or at the rear of the membrane disc to equalize flow path lengths and reduce the residence time distribution [71].…”

Section: Axial Flow Membrane Modulementioning

confidence: 99%

Membrane Chromatography and Fractionation of Proteins from Whey—A Review

et al. 2022

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Membrane chromatography (MC) is an emerging bioseparation technology combining the principles of membrane filtration and chromatography. In this process, one type of molecule is adsorbed in the stationary phase, whereas the other type of molecule is passed through the membrane pores without affecting the adsorbed molecule. In subsequent the step, the adsorbed molecule is recovered by an elution buffer with a unique ionic strength and pH. Functionalized microfiltration membranes are usually used in radial flow, axial flow, and lateral flow membrane modules in MC systems. In the MC process, the transport of a solute to a stationary phase is mainly achieved through convection and minimum pore diffusion. Therefore, mass transfer resistance and pressure drop become insignificant. Other characteristics of MC systems are a minimum clogging tendency in the stationary phase, the capability of operating with a high mobile phase flow rate, and the disposable (short term) application of stationary phase. The development and application of MC systems for the fractionation of individual proteins from whey for investigation and industrial-scale production are promising. A significant income from individual whey proteins together with the marketing of dairy foods may provide a new commercial outlook in dairy industry. In this review, information about the development of a MC system and its applications for the fractionation of individual protein from whey are presented in comprehensive manner.

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