“…Castillo Castillo et al (2017 presented DGO algorithms to solve mixedinteger quadratically constrained quadratic programs (MIQCQPs) arising in large-scale refinery planning that performed similarly to the commercial solvers BARON (Sahinidis, 2004) and ANTIGONE (Misener and Floudas, 2014). The approach relies on mixed-integer linear programming (MILP) relaxations, derived from piecewise McCormick envelopes (Castro, 2015;Gounaris et al, 2009;McCormick, 1976) or the multiparametric disaggregation technique (Andrade et al, 2018;Castro, 2016;Kolodziej et al, 2013;Teles et al, 2013), and on the reduction of the variables domain through optimality-based bound tightening (OBBT) (Castro and Grossmann, 2014;Puranik and Sahinidis, 2017).…”