Enhancing the oral bioavailability of asenapine maleate with bio-enhancer: An in-silico assisted in-vivo pharmacokinetic study

Suresh, Akhil; Narayan, Reema; Tumala, Hari Prabath; Matcha, Saikumar; Mallayasamy, Surulivelrajan; Nayak, Yogendra; Pc, Jagadish; Nayak, Usha Y.

doi:10.1016/j.jddst.2022.103215

Cited by 2 publications

(1 citation statement)

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“…The percentage of a drug that really makes it to the tissues or cells that the drug was designed to affect is referred to as the drug's 'bioavailability', and it is defined as the amount of the drug that actually reaches its intended target areas [1][2][3]. It is essential to have a solid understanding of the various routes of drug administration in order to have a firm grasp on bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Natural bio-enhancer for bioavailability enhancement

Keservani,

Ahire,

Singh

et al. 2023

Current Issues in Pharmacy and Medical Sciences

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There is a connection between bioavailability and absorption. In the field of pharmacology, this is referred to as a category of absorption and is defined as the proportion of a particular dosage of a drug that does not change and is absorbed into the systemic circulation. Both the overall absorption of medications and their specific bioavailability are important factors to consider in treatment. In this paper, we will go into great detail about the bioavailability of phytochemicals. We will also discuss the factors that influence bioavailability, the processes that improve bioavailability, and the phytochemicals that act as important bio enhancers, which are agents that improve the bioavailability of drugs.

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Section: Introductionmentioning

confidence: 99%

Natural bio-enhancer for bioavailability enhancement

Keservani,

Ahire,

Singh

et al. 2023

Current Issues in Pharmacy and Medical Sciences

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A Recent Review on Bio-availability Enhancement of Poorly Water-soluble Drugs by using Bioenhancer and Nanoparticulate Drug Delivery System

Mandal

Kumar

et al. 2022

CPD

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Background: Intravenous route of drug administration has maximum bioavailability, which shows 100% of the drug reaches blood circulation, whereas the oral administration, of drugs, are readily undergoing pre-systemic metabolism, which means the poor bioavailability of the drug and limited amount of drug reaches the target site. Introduction: Bioenhancers are substances having medicinal entities which enhance the bioavailability and efficacy of the active constituents of drugs. The enhanced bioavailability of drugs may lead to dose reduction, which may further lead to lessening the cost and undesired side effects associated with the drugs. Methods: The solid lipid nanoparticles (SLNs) loaded with ketoprofen made from carnauba wax and beeswax. It was discovered that when the drug-loaded SLNs were mixed with egg-lecithin and Tween-80, as well as when the total surfactant concentration was increased, the average particle size of the drug-loaded SLNs decreased. Result: The drug-loaded nanoparticles, when given in combination with bio-enhancers such as piperine and quercetin enhanced the effectiveness of the drug. The Area Under Curve (AUC) was increased when the drug was coupled with bio-enhancers. Based on the findings, it can be concluded that piperine and quercetin when used with drug-loaded nanoparticles improve their therapeutic effectiveness. Conclusion: Bioenhancers are crucial to amplifying the bioavailability of many synthetic drugs. These attributes are useful to reduce the dose of drugs as well as increase the therapeutic efficacy of drugs that has poor bioavailability.

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Enhancing the oral bioavailability of asenapine maleate with bio-enhancer: An in-silico assisted in-vivo pharmacokinetic study

Cited by 2 publications

References 72 publications

Natural bio-enhancer for bioavailability enhancement

Natural bio-enhancer for bioavailability enhancement

A Recent Review on Bio-availability Enhancement of Poorly Water-soluble Drugs by using Bioenhancer and Nanoparticulate Drug Delivery System

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