2024
DOI: 10.1007/s40820-024-01438-w
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Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host–Guest Complexation for Photodynamic Therapy

Rongrong Li,
Tianfeng Yang,
Xiuhong Peng
et al.

Abstract: The development of supramolecular hosts which can efficiently encapsulate photosensitizers to improve the photodynamic efficacy holds great promise for cancer therapy. Here, we report two perylene diimide-based metallacages that can form stable host–guest complexes with planar conjugated molecules including polycyclic aromatic hydrocarbons and photosensitizers (hypocrellin A). Such host–guest complexation not only prevents the aggregation of photosensitizers in aqueous environments, but also offers fluorescenc… Show more

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Cited by 5 publications
(2 citation statements)
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“…7−12 Despite good PDT efficacy, the conventional PSs cannot real-time monitor the phototherapeutic effect, which leads to problems such as overtreatment or delay of treatment during the PDT process. 13,14 Therefore, the development of new PSs with good photodynamic therapy efficacy and self-reporting properties is highly desired.…”
Section: ■ Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…7−12 Despite good PDT efficacy, the conventional PSs cannot real-time monitor the phototherapeutic effect, which leads to problems such as overtreatment or delay of treatment during the PDT process. 13,14 Therefore, the development of new PSs with good photodynamic therapy efficacy and self-reporting properties is highly desired.…”
Section: ■ Introductionmentioning
confidence: 99%
“…So much effort has been made to develop effective diagnostic and therapeutic techniques. , In recent years, photodynamic therapy (PDT) has become a hopeful technology for cancer treatment due to the distinctive benefits of noninvasive therapy, high specificity, controllability, and high spatiotemporal precision. , PDT is a photochemical-based treatment approach that involves the use of photosensitizers (PSs) to produce highly cytotoxic reactive oxygen species (ROS) upon light irradiation for inducing cancer cell death . A wide range of PSs has been developed, such as organic fluorophores, transition metal complexes, and nanomaterials. Despite good PDT efficacy, the conventional PSs cannot real-time monitor the phototherapeutic effect, which leads to problems such as overtreatment or delay of treatment during the PDT process. , Therefore, the development of new PSs with good photodynamic therapy efficacy and self-reporting properties is highly desired.…”
Section: Introductionmentioning
confidence: 99%