Enhancing the physical stability and bioaccessibility of curcumin emulsions through the interaction of whey protein isolate and soybean lecithin

Pan, Yue; Liu, Lu; Li, Jiayu; Zhu, Bin; Li, Xiaodong; Cheng, Jinju; Muneeb, Muhammad; Kouame, Kouadio Jean Eric-parfait; Jiang, Xin

doi:10.1016/j.fbio.2024.103676

Cited by 2 publications

(1 citation statement)

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“…Microscopic observation of the ELPC displayed both fibers and beads instead of stable bead-free fibers. In addition, the self-assembled emulsion had a relatively large average droplet size around 675 nm, which is apparently larger than the droplets of routine nano-emulsions [ 36 , 37 , 38 ]. These observations implied that further tuning of the ELPC formulation was necessary, which could possibly promote the delivery of TC.…”

Section: Discussionmentioning

confidence: 99%

Characterizations on a GRAS Electrospun Lipid–Polymer Composite Loaded with Tetrahydrocurcumin

Lin,

Li,

Huang

2024

Foods

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Electrospun/sprayed fiber films and nanoparticles were broadly studied as encapsulation techniques for bioactive compounds. Nevertheless, many of them involved using non-volatile toxic solvents or non-biodegradable polymers that were not suitable for oral consumption, thus rather limiting their application. In this research, a novel electrospun lipid–polymer composite (ELPC) was fabricated with whole generally recognized as safe (GRAS) materials including gelatin, medium chain triglyceride (MCT) and lecithin. A water-insoluble bioactive compound, tetrahydrocurcumin (TC), was encapsulated in the ELPC to enhance its delivery. Confocal laser scanning microscopy (CLSM) was utilized to examine the morphology of this ELPC and found that it was in a status between electrospun fibers and electrosprayed particles. It was able to form self-assembled emulsions (droplets visualized by CLSM) to deliver active compounds. In addition, this gelatin-based ELPC self-assembled emulsion was able to form a special emulsion gel. CLSM observation of this gel displayed that the lipophilic contents of the ELPC were encapsulated within the cluster of the hydrophilic gelatin gel network. The FTIR spectrum of the TC-loaded ELPC did not show the fingerprint pattern of crystalline TC, while it displayed the aliphatic hydrocarbon stretches from MCT and lecithin. The dissolution experiment demonstrated a relatively linear release profile of TC from the ELPC. The lipid digestion assay displayed a rapid digestion of triglycerides in the first 3–6 min, with a high extent of lipolysis. A Caco-2 intestinal monolayer transport study was performed. The ELPC delivered more TC in the upward direction than downwards. MTT study results did not report cytotoxicity for both pure TC and the ELPC-encapsulated TC under 15 μg/mL. Caco-2 cellular uptake was visualized by CLSM and semi-quantified to estimate the accumulation rate of TC in the cells over time.

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Section: Discussionmentioning

confidence: 99%