2024
DOI: 10.1002/adhm.202303320
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Enhancing the Repair of Substantial Volumetric Muscle Loss by Creating Different Levels of Blood Vessel Networks Using Pre‐Vascularized Nerve Hydrogel Implants

Shih‐Yen Wei,
Po‐Yu Chen,
Min‐Chun Tsai
et al.

Abstract: Volumetric muscle loss (VML) is a significant loss of muscle tissue due to trauma or surgery, resulting in scarring, minimal regeneration, and notable fibrosis. This leads to permanent declines in muscle mass and function. One potential approach to enhance recovery in substantial VML is to restore vascular and neural networks at the injury site. However, the processes of neovascularization and tissue integration at the muscle injury site have not been widely studied. Collagen hydrogels have been explored as sc… Show more

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