Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells

Liang, Jie; Zhou, Fanlin; Xiong, Xiaomin; Zhang, Xiong; Li, Shijie; Li, Xiaoju; Gao, Minna; Liu, Yu

doi:10.18632/aging.102235

Cited by 14 publications

(10 citation statements)

References 58 publications

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“…Therefore, balanced autophagosome production and degradation are a prerequisite for neuroprotection in AD. In our previous study, we observed that several autophagosomes could not successfully combine with lysosomes to form mature autophagic lysosomes in AD model N2a/ APP695swe cells transfected with a double-labeled autophagic adenovirus (mRFP-GFP-LC3) [26]. Dynein intermediate chain (DIC) is required for autophagosome transport and autophagic lysosome maturation, and it has been reported that DIC expression is downregulated in the brain of patients with AD [27].…”

Section: Agingmentioning

confidence: 99%

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Zhou

Xiong

et al. 2020

Aging

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INTRODUCTION Macroautophagy, or simply autophagy, maintains cell viability, particularly under stress, by recycling the constituent components of damaged macromolecules and organelles through a specific autophagic vesiclelysosome degradation pathway [1-4]. In neurons, nascent autophagic vesicles (autophagosomes) are mainly formed in distal axons and thus require longdistance retrograde transport to merge with degradative www.aging-us.com

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Section: Agingmentioning

confidence: 99%

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Zhou

Xiong

et al. 2020

Aging

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“…In addition to rapamycin, curcumin, a natural compound that inhibits the PI3K/Akt/mTOR pathway, has been described as having a therapeutic effect on neurodegenerative diseases [228,229]. Curcumin has been shown to enhance the expression levels of autophagy-related proteins, such as Beclin-1, ATG5, or ATG16L1, and motor proteins essential for retrograde axonal transport, resulting in an increase of the autophagic flux and the clearance of intracellular aggregates [113,228,230,231].…”

Section: Mtor-dependent Autophagy Inducing Agentsmentioning

confidence: 99%

Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates

Park

Kang

Lee

2020

IJMS

138

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Cells have developed elaborate quality-control mechanisms for proteins and organelles to maintain cellular homeostasis. Such quality-control mechanisms are maintained by conformational folding via molecular chaperones and by degradation through the ubiquitin-proteasome or autophagy-lysosome system. Accumulating evidence suggests that impaired autophagy contributes to the accumulation of intracellular inclusion bodies consisting of misfolded proteins, which is a hallmark of most neurodegenerative diseases. In addition, genetic mutations in core autophagy-related genes have been reported to be linked to neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Conversely, the pathogenic proteins, such as amyloid β and α-synuclein, are detrimental to the autophagy pathway. Here, we review the recent advances in understanding the relationship between autophagic defects and the pathogenesis of neurodegenerative diseases and suggest autophagy induction as a promising strategy for the treatment of these conditions.

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“…A of AMPK activity (226)(227)(228)(229)(230). Moreover, curcumin may promotes autophagic proteins and their retrograde axonal transport (231).…”

Section: Neurodegenerative Diseases 821 Alzheimer's Diseasementioning

confidence: 99%

The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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Curcumin is the major phytoconstituent found in the rhizomes of Curcuma longa L. Preparations derived from the rhizome of the plant, referred as turmeric, have been used for centuries in the traditional Indian system of medicine. The recent literature has shown curcumin as one of the most interesting pleiotropic nutraceuticals capable of interacting with different molecular targets involved in chronic diseases. The present review summarizes and critically discusses the very recent literature published between 2018 and 2021. We focused on the preclinical pharmacological actions of curcumin in relation to its possible clinical application in several pathophysiological states and disturbances including inflammation and pain, as well as metabolic, cardiovascular, dermatological, and central nervous system diseases. The most relevant molecular targets of curcumin, such as transcription factors, pro-inflammatory mediators, enzymes, and protein kinase as well as pharmacokinetics in humans are also reviewed.

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Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells

Cited by 14 publications

References 58 publications

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates

The pharmacological basis of the curcumin nutraceutical uses: an update

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