Enhancing the spatial resolution of hyperpolarized carbon‐13 MRI of human brain metabolism using structure guidance

Abstract

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Volume‐Controlled 19F MR Ventilation Imaging of Fluorinated Gas

“…For future examinations, an additional low‐resolution proton image could be recorded in every breath‐hold, which subsequently enables registration of 19 F gas images onto the high‐resolution proton image recorded in the beginning as previously implemented 32 . Structure‐guided image reconstruction could compensate for resulting loss of acquisition time for gas imaging 33 …”

“…32 Structureguided image reconstruction could compensate for resulting loss of acquisition time for gas imaging. 33 The model functions applied for FV and WI fitting are mono-exponential, assuming the same amount of C 3 F 8 in every breath. For examinations without volume control, the gas washin may not be mono-exponential since breathing volumes can vary.…”

Deuterium metabolic imaging and hyperpolarized13C-MRI of the normal human brain at clinical field strength reveals differential cerebral metabolism

“…Intravenous administration of 13 C-pyruvate enabled rapid metabolite uptake and high SNR. Hyperpolarized 13 C-pyruvate is rapidly transported across the normal blood-brain barrier, and within the cell it is metabolized into both 13 C-lactate and 13 C-bicarbonate, with marked regional variations in metabolism observable across the brain (Dwork et al, 2021; Ehrhardt et al, 2021; Grist et al, 2019; Lee et al, 2020; Ma and Park, 2020). A previous study has compared DMI and 13 C-HPMRI pre-clinically using a 4.7 T system (von Morze et al, 2021), but given that the 13 C-bicarbonate signal was undetectable, a direct comparison of the glycolytic/oxidative metabolism using each method could not be undertaken.…”

Single cell metabolism: current and future trends

“…From (Lita et al, 2021) with permission large amounts of compound are needed, such that Magnetic Resonance Imaging (MRI) cannot achieve single cell or near single cell resolution. Sensitivity enhancement via dynamic nuclear polarization (DNP) for example allows for localized kinetic analysis of a few reactions, but is still limited to mm 3 sized volumes (Ehrhardt et al, 2022). The great advantage of MRI is that the imaging is in vivo and can be carried out at greater depth than optical imaging (Ahn et al, 2019;Dang et al, 2019).…”