Enhancing the stability of zein/fucoidan composite nanoparticles with calcium ions for quercetin delivery

Zhang, Hong; Feng, Haozhan; Ling, Junhong; Ouyang, Xiaolong; Song, Xiaoyong

doi:10.1016/j.ijbiomac.2021.11.039

Cited by 52 publications

(27 citation statements)

References 61 publications

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“…The stability and drug release are essential parameters for the efficacy of encapsulated drugs in NPs ( Jana et al, 2020 ; Zhang H. et al, 2021 ). Therefore, the stability of BSA@Rb1 NPs and Man-BSA@Rb1 NPs was first evaluated in PBS (pH 7.4) media.…”

Section: Resultsmentioning

confidence: 99%

Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Ginsenoside Rb1 is a potential anti-inflammatory natural molecule, but its therapeutic efficacy was tremendously hampered by the low solubility and non-targeted delivery. In this study, we innovatively developed a mannose (Man)-modified albumin bovine serum albumin carrier (Man-BSA) to overcome the previously mentioned dilemmas of Rb1. The constructed Man-BSA@Rb1 NPs could improve the solubility and increase the cellular uptake of Rb1, finally leading to the enhanced anti-inflammatory effects. The robust therapeutics of Man-BSA@Rb1 NPs were measured in terms of nitrite, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels, which might be achieved by potently inhibiting nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways in lipopolysaccharide (LPS)-induced Raw264.7 cells. Moreover, the therapeutic efficacy of Man-BSA@Rb1 NPs was further confirmed in the d-Gal/LPS-induced liver injury model. The results indicated that Man-BSA may offer a promising system to improve the anti-inflammatory therapy of Rb1.

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Section: Resultsmentioning

confidence: 99%

Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…The rapid uptake of nanoparticles by the reticuloendothelial system causes the carrier to circulate in the blood for a short amount of time to reach the minimum therapeutic concentration. NDDS with particle sizes ranging from 1 to 1000 nm systematically reach the tumor site and release their active drugs [14,15]. Stimulation-responsive functional NDDS target the release of drugs upon specific endogenous (pH, redox, ROS) and exogenous (light, heat, magnetic) stimuli that can be constructed, considering the acidic and reductive characteristics of the tumor cell microenvironment [16].…”

Section: Introductionmentioning

confidence: 99%

Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells

et al. 2022

Self Cite

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We designed and synthesized aminated mesoporous silica (MSN-NH2), and functionally grafted alginate oligosaccharides (AOS) on its surface to get MSN-NH2-AOS nanoparticles as a delivery vehicle for the fat-soluble model drug curcumin (Cur). Dynamic light scattering, thermogravimetric analysis, and X-ray photoelectron spectroscopy were used to characterize the structure and performance of MSN-NH2-AOS. The nano-MSN-NH2-AOS preparation process was optimized, and the drug loading and encapsulation efficiencies of nano-MSN-NH2-AOS were investigated. The encapsulation efficiency of the MSN-NH2-Cur-AOS nanoparticles was up to 91.24 ± 1.23%. The pH-sensitive AOS coating made the total release rate of Cur only 28.9 ± 1.6% under neutral conditions and 67.5 ± 1% under acidic conditions. According to the results of in vitro anti-tumor studies conducted by MTT and cellular uptake assays, the MSN-NH2-Cur-AOS nanoparticles were more easily absorbed by colon cancer cells than free Cur, achieving a high tumor cell targeting efficiency. Moreover, when the concentration of Cur reached 50 μg/mL, MSN-NH2-Cur-AOS nanoparticles showed strong cytotoxicity against tumor cells, indicating that MSN-NH2-AOS might be a promising tool as a novel fat-soluble anticancer drug carrier.

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“…To reduce these limitations, it was reported to be an effective strategy to coat zein nanoparticlse with other macromolecules, e.g. phospholipids, , polysaccharides, − proteins, , etc. In addition, the -NH 2 and COOH groups of the zein molecule were usually conjugated with targeting ligands (e.g., folic acid and lactoferrin) to fulfill the site-specific drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Rational Fabrication of Folate-Conjugated Zein/Soy Lecithin/Carboxymethyl Chitosan Core–Shell Nanoparticles for Delivery of Docetaxel

Zhang

et al. 2022

ACS Omega

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The objective of this work is to design and fabricate a natural zein-based nanocomposite with core–shell structure for the delivery of anticancer drugs. As for the design, folate-conjugated zein (Fa-zein) was synthesized as the inner hydrophobic core; soy lecithin (SL) and carboxymethyl chitosan (CMC) were selected as coating components to form an outer shell. As for fabrication, a novel and appropriate atomizing/antisolvent precipitation process was established. The results indicated that Fa-zein/SL/CMC core–shell nanoparticles (FZLC NPs) were successfully produced at a suitable mass ratio of Fa-zein/SL/CMC (100:30:10) and the freeze-dried FZLC powder showed a perfect redispersibility and stability in water. After that, docetaxel (DTX) as a model drug was encapsulated into FZLC NPs at different mass ratios of DTX to FZLC ( MR ). When MR = 1:15, DTX/FZLC NPs were obtained with high encapsulation efficiency (79.22 ± 0.37%), small particle size (206.9 ± 48.73 nm), and high zeta potential (−41.8 ± 3.97 mV). DTX was dispersed in the inner core of the FZLC matrix in an amorphous state. The results proved that DTX/FZLC NPs could increase the DTX dissolution, sustain the DTX release, and enhance the DTX cytotoxicity significantly. The present study provides insight into the formation of zein-based complex nanocarriers for the delivery of anticancer drugs.

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Enhancing the stability of zein/fucoidan composite nanoparticles with calcium ions for quercetin delivery

Cited by 52 publications

References 61 publications

Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy

Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy

Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells

Rational Fabrication of Folate-Conjugated Zein/Soy Lecithin/Carboxymethyl Chitosan Core–Shell Nanoparticles for Delivery of Docetaxel

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