Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

Yang, Hong-Chang; Huang, Kai‐Wen; Liao, Shu; Horng, Herng-Er; Chieh, Jen Jie; Chen, H. H.; Chen, Ming‐Ju; Chen, K. L.; Wang, Li Min

doi:10.1063/1.4774291

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…There is some merit in NMR/MRI at ULF: (1) enhanced image contrast using T 1 -weighted MRI [2]; (2) simultaneous detection by magnetoencephalography (MEG) and MRI [3]; (3) reduced susceptibility artifacts and reduced screening allowing MRI in the presence of metals [4,5], etc. Despite the weak signals in ULF NMR/MRI progress has been made, such as the discrimination of tumors [6,7] etc.…”

Section: Introductionmentioning

confidence: 99%

A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T _c SQUID-based NMR in ultralow magnetic fields

Liao

2017

Supercond. Sci. Technol.

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We study the concentration dependence of spin–lattice relaxation rates, T1−1, of glucose, fructose, sucrose and cherries by using high-Tc SQUID-based NMR at magnetic fields of ∼97 μT. The detected NMR signal, Sy(TBp), is fitted to [1 − exp(−TBp/T1)] to derive T1−1, where Sy(TBp) is the strength of the NMR signal, TBp is the duration of pre-polarization and T1−1 is the spin–lattice relaxation rate. It was found that T1−1 increases as the sugar concentrations increase. The increased T1−1 is due to the presence of more molecules in the surroundings, which increases the spin–lattice interaction and in turn enhances T1−1. The T1−1 versus degrees Brix curve provides a basis for determining unknown Brix values for cherries as well as other fruits.

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Section: Introductionmentioning

confidence: 99%

A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T _c SQUID-based NMR in ultralow magnetic fields

Liao

2017

Supercond. Sci. Technol.

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“…Magnetic nanoparticles interest researchers because of their potential applications in biomedicine, such as protein purification [1], magnetofection [2], tomographic imaging [3], magnetic resonance imaging [4][5][6], magnetic immunoassays [7,8], tumor diagnosis [9], and hyperthermia therapy [10]. In magnetic immunoassays, magnetic nanoparticles are first biofunctionalized with antibodies to obtain biofunctionalized magnetic nanoparticles (BMNs), which are then dissolved in solutions to form magnetic reagents.…”

Section: Introductionmentioning

confidence: 99%

Assaying Carcinoembryonic Antigens by Normalized Saturation Magnetization

Huang¹,

Chieh²,

Shi³

et al. 2016

Nano Online

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Biofunctionalized magnetic nanoparticles (BMNs) that provide unique advantages have been extensively used to develop immunoassay methods. However, these developed magnetic methods have been used only for specific immunoassays and not in studies of magnetic characteristics of materials. In this study, a common vibration sample magnetometer (VSM) was used for the measurement of the hysteresis loop for different carcinoembryonic antigens (CEA) concentrations (Φ CEA) based on the synthesized BMNs with anti-CEA coating. Additionally, magnetic parameters such as magnetization (M), remanent magnetization (M R), saturation magnetization (M S), and normalized parameters (ΔM R /M R and ΔM S /M S) were studied. Here, ΔM R and ΔM s were defined as the difference between any Φ CEA and zero Φ CEA. The parameters M, ΔM R , and ΔM S increased with Φ CEA , and ΔM S showed the largest increase. Magnetic clusters produced by the conjugation of the BMNs to CEAs showed a ΔM S greater than that of BMNs. Furthermore, the relationship between ΔM S /M S and Φ CEA could be described by a characteristic logistic function, which was appropriate for assaying the amount of CEAs. This analytic ΔM S /M S and the BMNs used in general magnetic immunoassays can be used for upgrading the functions of the VSM and for studying the magnetic characteristics of materials.

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“…Magnetic nanoparticles interest researchers because of their potential applications in biomedicine, such as protein purification [ 1 ], magnetofection [ 2 ], tomographic imaging [ 3 ], magnetic resonance imaging [ 4 – 6 ], magnetic immunoassays [ 7 , 8 ], tumor diagnosis [ 9 ], and hyperthermia therapy [ 10 ]. In magnetic immunoassays, magnetic nanoparticles are first biofunctionalized with antibodies to obtain biofunctionalized magnetic nanoparticles (BMNs), which are then dissolved in solutions to form magnetic reagents.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, developing a biodetection system featuring an alternative detection mechanism and high detection sensitivity is crucial. A wash-free immunomagnetic reduction (IMR) method based on ac magnetic susceptibility reduction has been proposed [ 19 ], and various studies have demonstrated the sensitive detection of biomolecules, such as nucleic acids [ 20 ], biomarkers (for diagnosing Alzheimer’s disease) [ 6 ], alpha-fetoprotein (for detecting liver tumors) [ 7 ], and human C-reactive protein (for diagnosing inflammation) [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Assaying Carcinoembryonic Antigens by Normalized Saturation Magnetization

et al. 2015

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Biofunctionalized magnetic nanoparticles (BMNs) that provide unique advantages have been extensively used to develop immunoassay methods. However, these developed magnetic methods have been used only for specific immunoassays and not in studies of magnetic characteristics of materials. In this study, a common vibration sample magnetometer (VSM) was used for the measurement of the hysteresis loop for different carcinoembryonic antigens (CEA) concentrations (ΦCEA) based on the synthesized BMNs with anti-CEA coating. Additionally, magnetic parameters such as magnetization (M), remanent magnetization (MR), saturation magnetization (MS), and normalized parameters (ΔMR/MR and ΔMS/MS) were studied. Here, ΔMR and ΔMs were defined as the difference between any ΦCEA and zero ΦCEA. The parameters M, ΔMR, and ΔMS increased with ΦCEA, and ΔMS showed the largest increase. Magnetic clusters produced by the conjugation of the BMNs to CEAs showed a ΔMS greater than that of BMNs. Furthermore, the relationship between ΔMS/MS and ΦCEA could be described by a characteristic logistic function, which was appropriate for assaying the amount of CEAs. This analytic ΔMS/MS and the BMNs used in general magnetic immunoassays can be used for upgrading the functions of the VSM and for studying the magnetic characteristics of materials.

show abstract

Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

Cited by 10 publications

References 22 publications

A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T _c SQUID-based NMR in ultralow magnetic fields

A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T _c SQUID-based NMR in ultralow magnetic fields

Assaying Carcinoembryonic Antigens by Normalized Saturation Magnetization

Assaying Carcinoembryonic Antigens by Normalized Saturation Magnetization

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Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

Cited by 10 publications

References 22 publications

A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T c SQUID-based NMR in ultralow magnetic fields

A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T c SQUID-based NMR in ultralow magnetic fields

Assaying Carcinoembryonic Antigens by Normalized Saturation Magnetization

Assaying Carcinoembryonic Antigens by Normalized Saturation Magnetization

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A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T _c SQUID-based NMR in ultralow magnetic fields

A study of spin–lattice relaxation rates of glucose, fructose, sucrose and cherries using high-T _c SQUID-based NMR in ultralow magnetic fields