Enhancing the water dispersibility of paclitaxel by complexation with hydrophobic peptides

Inada, Asuka; Oshima, Tatsuya; Baba, Yoshihiro

doi:10.1016/j.colsurfb.2015.08.004

Cited by 13 publications

(11 citation statements)

References 42 publications

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“…However, the solubility of the Indo complex prepared using fraction A was not as high, despite it containing relatively hydrophobic peptides with high molecular weights. This result differs from that for the Ptx complexes with Pep fractions, in which fraction A was the most effective in enhancing Ptx water dispersibility (Inada et al, 2015). For Ibu and Pre, water solubility increased with increasing hydrophobicity of the Pep fractions.…”

Section: Water Solubility Of Complexes Between Drugs Andcontrasting

confidence: 74%

“…In addition, the particle size of the complexes in fractions F1-F7 could not be measured using DLS, suggesting that the complexes in aqueous media were sufficiently small to pass through ultrafiltration membranes. These results differ from those for complexes between Ptx and Pep; the PtxPep complex is a hydrocolloidal material in aqueous media and the particle size is around 150-200 nm (Inada et al, 2015). Moreover, the coenzyme Q 10 -albumin peptide complex is also a hydrocolloidal material in aqueous media and the particle size is around 170-280 nm (Matsushita et al, 2013).…”

Section: Materials Distribution and Particle Size Analysiscontrasting

confidence: 48%

“…Subsequently, Pep was fractionated by stepwise ammonium sulfate precipitation, followed by ultrafiltration using UF membranes with various MWCOs (Figure 2), to find effective peptides that interact with drugs (Inada et al, 2015). Pep (22.5 g) was dissolved in 450 mL of Milli-Q water.…”

Section: Preparation Of Pep and Pep Fractionsmentioning

confidence: 99%

“…It should be noted that the solubility of Pre-Pep was almost independent of pH, which differs from the behavior of Indo-Pep and Ibu-Pep. The apparent water solubility of the complex between Pep and Ptx is also independent of pH (Inada et al, 2015). Because neither Pre nor Ptx contain dissociable groups, the water solubility of complexes between Pep and most nonionic drugs is independent of pH.…”

Section: Dependency Of Water Solubility On Ph For the Three Drug Compmentioning

confidence: 99%

“…The sequences of part of the peptides in each fraction were identified (Inada et al, 2015). Figures 4(a), (b) and (c) show the solubility of the complexes between the three drugs and Pep fractions (A-L).…”

Section: Water Solubility Of Complexes Between Drugs Andmentioning

confidence: 99%

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Water Solubility of Complexes between a Peptide Mixture and Poorly Water-Soluble Ionic and Nonionic Drugs

Inada

Wang

Oshima

et al. 2016

J. Chem. Eng. Japan / JCEJ

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Recently, a peptide mixture (Pep) obtained as a casein hydrolysate was found to be e ective for enhancing the water solubility or water dispersibility for poorly water-soluble drugs. In the present study, complexation of Pep with ionic and nonionic drugs indomethacin (Indo), ibuprofen (Ibu), and prednisolone (Pre) was studied. The water solubility of complexes containing Indo and Ibu, both of which have a dissociable carboxylic group, increased with increasing pH. In contrast, the water solubility of a complex containing Pre, which does not contain dissociable groups, was almost independent of pH. As all three complexes were permeable through an ultra ltration membrane with a molecular-weight cuto 10,000 gmol 1 , the complexes were present not as colloidal materials but relatively small species in aqueous media. Moreover, Indo, Ibu, and Pre were complexed with twelve peptide fractions, which were derived from Pep by combining ammonium sulfate precipitation with ultra ltration. Water solubility of the drugs increased with all Pep-derived fractions, suggesting that various peptides interact with the drugs.

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Section: Water Solubility Of Complexes Between Drugs Andcontrasting

confidence: 74%

Section: Materials Distribution and Particle Size Analysiscontrasting

confidence: 48%

Section: Preparation Of Pep and Pep Fractionsmentioning

confidence: 99%

Section: Dependency Of Water Solubility On Ph For the Three Drug Compmentioning

confidence: 99%

Section: Water Solubility Of Complexes Between Drugs Andmentioning

confidence: 99%

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