Enhancing Therapeutic Efficacy of Donepezil by Combined Therapy: A Comprehensive Review

Rong, Xi; Jiang, Liwei; Qu, Meijie; Hassan, Syed Shams ul; Liu, Zongchao

doi:10.2174/1381612826666201023144836

Cited by 37 publications

(20 citation statements)

References 59 publications

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“…The commonly used anti-AD drugs (donepezil and rivastigmine) seem as viable alternatives (Karasova et al 2020a, b). Their toxicity, brain distribution, and adverse effects have been thoroughly explored (Bures et al 2020(Bures et al , 2021Korabecny et al 2019;Nguyen et al 2021;Rong et al 2021;Valis et al 2017;Zemek et al 2014). While pyridostigmine administered alone failed, donepezil decreased soman's acute toxicity significantly (the protective ratio 1.35).…”

Section: Discussionmentioning

confidence: 99%

Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice

Kassa

Karasová

2021

Neurotox Res

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Nerve agents pose a real threat to both the military and civil populations, but the current treatment of the poisoning is unsatisfactory. Thus, we studied the efficacy of prophylactic use of memantine alone or in combination with clinically used reversible acetylcholinesterase inhibitors (pyridostigmine, donepezil, rivastigmine) against soman. In addition, we tested their influence on post-exposure therapy consisting of atropine and asoxime. Pyridostigmine alone failed to decrease the acute toxicity of soman. But all clinically used acetylcholinesterase inhibitors administered alone reduced the acute toxicity, with donepezil showing the best efficacy. The combination of memantine with reversible acetylcholinesterase inhibitors attenuated soman acute toxicity significantly. The pretreatment administered alone or in combinations influenced the efficacy of post-exposure treatment in a similar fashion: (i) pyridostigmine or memantine alone did not affect the antidotal treatment, (ii) centrally acting reversible acetylcholinesterase inhibitors alone increased the antidotal treatment slightly, (iii) combination of memantine with reversible acetylcholinesterase inhibitors increased the antidotal treatment more markedly. In conclusion, memantine alone failed to decrease the acute toxicity of soman or increase post-exposure antidotal treatment efficacy. The combination of memantine with donepezil significantly increased post-exposure effectiveness (together 5.12, pretreatment alone 1.72). Both drugs, when applied together, mitigate soman toxicity and boost post-exposure treatment.

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Section: Discussionmentioning

confidence: 99%

Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice

Kassa

Karasová

2021

Neurotox Res

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“…Gilead Sciences developed it for Ebola infection in 2017. Remdesivir, for example, can repress SARS-CoV and MERS-CoV replication in in vitro studies (Rong et al 2021 ; Agostini et al 2018 ). Remdesivir represses movement using human CoV receptors of bat CoV, SARS-CoV, and MERS-CoV strains, which can replicate in human epithelial cells and function like intermediate channels.…”

Section: Potential Treatmentsmentioning

confidence: 99%

Novel coronavirus pathogen in humans and animals: an overview on its social impact, economic impact, and potential treatments

Akter

Rahman

Bhattacharya

et al. 2021

Environ Sci Pollut Res

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In the light of thousands of infections and deaths, the World Health Organization (WHO) has declared the outbreak of coronavirus disease (COVID-19) a worldwide pandemic. It has spread to about 22 million people worldwide, with a total of 0.45 million expiries, limiting the movement of most people worldwide in the last 6 months. However, COVID-19 became the foremost health, economic, and humanitarian challenge of the twenty-first century. Measures intended to curb the pandemic of COVID-19 included travel bans, lockdowns, and social distances through shelter orders, which will further stop human activities suddenly and eventually impact the world and the national economy. The viral disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After SARS-CoV-2 virus and Middle East respiratory syndrome (MERS)-related CoV, COVID-19 is the third most significant lethal disease to humans. According to WHO, COVID-19 mortality exceeded that of SARS and MERS since COVID-19 was declared an international public health emergency. Genetic sequencing has recently established that COVID-19 is close to SARS-CoV and bat coronavirus which has not yet been recognized as the key cause of this pandemic outbreak, its transmission, and human pathogen mechanism. This review focuses on a brief introduction of novel coronavirus pathogens, including coronavirus in humans and animals, its taxonomic classification, symptoms, pathogenicity, social impact, economic impact, and potential treatment therapy for COVID-19.

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“…Acetylcholinesterase (AChE) inhibitors have recently been shown to be an effective clinical strategy for preserving acetylcholine levels and improving cholinergic activity, as stated by Colovic et al [ 98 ]. Inhibiting AChE and Butyrylcholinesterase (BChE) has developed into a standard method for treating the symptoms of neurodegenerative diseases like Alzheimer’s disease [ 99 ].…”

Section: Biological Activities Of Genus Scutellariamentioning

confidence: 99%

Phytochemical Profiling and Bio-Potentiality of Genus Scutellaria: Biomedical Approach

et al. 2022

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Scutellaria (Lamiaceae) comprises over 360 species. Based on its morphological structure of calyx, also known as Skullcap, it is herbaceous by habit and cosmopolitan by habitat. The species of Scutellaria are widely used in local communities as a natural remedy. The genus contributed over three hundred bioactive compounds mainly represented by flavonoids and phenols, chemical ingredients which serve as potential candidates for the therapy of various biological activities. Thus, the current review is an attempt to highlight the biological significance and its correlation to various isolated bioactive ingredients including flavonoids, terpenoids, phenols, alkaloids, and steroids. However, flavonoids were the dominant group observed. The findings of the Scutellaria reveal that due to its affluent basis of numerous chemical ingredients it has a diverse range of pharmacological potentials, such as antimicrobial, antioxidant, antifeedant, enzyme inhibition, anti-inflammatory, and analgesic significance. Currently, various bioactive ingredients have been investigated for various biological activities from the genus Scutellaria in vitro and in vivo. Furthermore, these data help us to highlight its biomedical application and to isolate the responsible compounds to produce innovative medications as an alternative to synthetic drugs.

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Enhancing Therapeutic Efficacy of Donepezil by Combined Therapy: A Comprehensive Review

Cited by 37 publications

References 59 publications

Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice

Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice

Novel coronavirus pathogen in humans and animals: an overview on its social impact, economic impact, and potential treatments

Phytochemical Profiling and Bio-Potentiality of Genus Scutellaria: Biomedical Approach

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