Enhancing Transdermal Drug Delivery with Electroporation

Abstract

The application of electroporation to enhance transdermal delivery has opened up a new possibility to introduce larger molecules such as peptide hormones and vaccines as well as minigenes and RNAi etc. through the transdermal route. Many devices have been developed to deliver the pulse electric field needed to permeate the skin. These devices include both non-puncturing surface electrodes as well as puncturing electrodes of different geometrical arrangements. The latter type uses electroporation only to increase uptake of molecules injected through the puncturing electrode or syringe. Different electroporation protocols have been developed to maximize transport, uptake and minimizing pain. Synergistic effect of chemical enhancers and physical (sonic, vibrational and thermal) treatments are used to enhance the transport. This article reviews the patents pertaining to the instrumentation as well as application protocols of transdermal delivery, uptake enhancement and interstitial fluid sampling by electroporation.

Efficient Transdermal Delivery of Alendronate, a Nitrogen-Containing Bisphosphonate, Using Tip-Loaded Self-Dissolving Microneedle Arrays for the Treatment of Osteoporosis

“…The stratum corneum in the outermost layer of the skin restricts the skin penetration of hydrophilic and macromolecular drugs [ 4 , 5 ]. In order to solve this problem, a number of methods to improve transdermal drug transport have been evaluated, including chemical absorption enhancers [ 6 ], iontophoresis [ 7 ], sonophoresis [ 8 ], electroporation [ 9 , 10 ] and microneedle arrays (MN) [ 11 ]. Among these techniques, MN is an effective way to deliver macromolecular and hydrophilic drugs into systemic circulation from the skin.…”