2022
DOI: 10.1021/acs.jpca.2c05164
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Enhancing Weak-Signal Extraction for Single-Molecule Localization Microscopy

Abstract: Single-molecule localization microscopy (SMLM) has been widely used in biological imaging due to its ultrahigh spatial resolution. However, due to the strategy of reducing photodamage to living cells, the fluorescence signals of emitters are usually weak and the detector noises become non-negligible, which leads to localization misalignments and signal losses, thus deteriorating the imaging capability of SMLM. Here, we propose an active modulation method to control the fluorescence of the probe emitters. It ac… Show more

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