Enigma of myoepithelioma at the base of tongue: A rare case report and review of literature

Karukayil, Deepthi; Stephen, Manju; Sunil, Anuradha; Mukunda, Archana

doi:10.4103/0973-1482.139380

Cited by 5 publications

(5 citation statements)

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“…7 At the time of publication, all current case reports of primary tongue MCC describe tumors that appear to have originated in the base of tongue. 8,9…”

Section: Discussionmentioning

confidence: 99%

“…7 At the time of publication, all current case reports of primary tongue MCC describe tumors that appear to have originated in the base of tongue. 8,9 Myoepithelial cells constitute an important component of glandular acini and ducts. They are normally located between the luminal epithelial cells and the basement membrane and have contractile function.…”

Section: History and Clinical Characteristics Of MCCmentioning

confidence: 99%

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Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature

Nicholas

Hanson

Meiklejohn

2019

Clin Med Insights Oncol

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Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue. Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Physical examination demonstrated a 2.5 cm ulcerative lesion of the anterior right oral tongue. An initial biopsy was consistent with moderately to poorly differentiated squamous cell carcinoma. Imaging included a positron emission tomography (PET)/computed tomography (CT) scan that demonstrated the right tongue lesion as well as hypermetabolic right level II adenopathy. The patient underwent surgical excision of the right tongue, upper aerodigestive tract endoscopy, and a bilateral supraomohyoid neck dissection. The tongue defect was closed primarily. Results: Final pathology of the surgical specimen demonstrated myoepithelial cell carcinoma. All of the margins were free of tumor and no cervical lymph nodes showed metastasis. Immunohistochemistry demonstrated myoepithelial differentiation. The tumor did not show EWSR1 gene rearrangement on genetic testing, suggesting salivary gland origin. Multidisciplinary tumor board evaluation recommended no adjuvant therapy. The patient recovered well after surgery and nearly a year later is without evidence of recurrent or residual disease. Conclusions: We present the first reported case of myoepithelial cell carcinoma with primary origin in the oral tongue and review the available literature on this unusual tumor. We discuss the clinical, pathological, and immunohistochemical features and treatment of myoepithelial cell carcinoma.

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“…7 At the time of publication, all current case reports of primary tongue MCC describe tumors that appear to have originated in the base of tongue. 8,9…”

Section: Discussionmentioning

confidence: 99%

Section: History and Clinical Characteristics Of MCCmentioning

confidence: 99%

Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature

Nicholas

Hanson

Meiklejohn

2019

Clin Med Insights Oncol

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“…Myoepitheliomas are believed to arise from stem cells that differentiate into myoepithelial cells. Both benign and malignant types have been described in literature and the most common differential diagnosis is pleomorphic adenoma 5. Some authors believe that myoepitheliomas are a monomorphic, single cell variant of pleomorphic adenoma while others believe that they are a separate spectrum of benign tumours with monomorphic adenomas (composed of pure epithelial cells) at one end and myoepitheliomas (composed of only myoepithelial cells) at the other end.…”

Section: Discussionmentioning

confidence: 99%

Clear cell, giant myoepithelioma of tongue base: a diagnostic and surgical challenge

2019

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Clear cell variant is a rare histological type of myoepithelioma seen in parotid and soft palate. This article describes clear cell variant of myoepithelioma in the tongue base, which has not been reported in the literature so far. A 34-year-old man presented with dysphagia and foreign body sensation of throat. Video laryngostroboscopy using a 70° rigid telescope showed a smooth globular mass in the oropharynx arising from the tongue base. Based on clinical and radiological findings, the lesion was considered as benign. Fine needle aspiration cytology was not attempted fearing risk of bleeding, aspiration and airway compromise. Hence, an excisional biopsy followed by definitive histopathological examination without frozen section was planned. The patient underwent coblator-assisted excision and subsequently sent for histopathological analysis. There were cuboidal cell nests with abundant clear cytoplasm which stained positive for p63 by immunohistochemistry. This helped in establishing the diagnosis of clear cell myoepithelioma.

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“…Their differential diagnosis includes a wide range of both benign and malignant tumours, depending on the predominant cell type: epithelioid, spindle, hyaline, clear cell [ 8 ]. In particular, the main differential diagnosis of myoepithelioma is pleomorphic adenoma (PA) [ 3 , 9 ]. The distinction between the two is based on the fact that PA contains abundant ducts, but no more than one duct every medium to high power field or no more than one small cluster of the duct.…”

Section: Discussionmentioning

confidence: 99%

“…The distinction between the two is based on the fact that PA contains abundant ducts, but no more than one duct every medium to high power field or no more than one small cluster of the duct. Moreover, a much greater amount of stromal component is found in the PA compared to myoepitheliomas [ 9 ]. However, myoepithelioma is made up of a variety of plasmacytoid, epithelioid, and spindle-shaped cells with focally abundant mucoid stroma and may easily be confused with a PA.…”

Section: Discussionmentioning

confidence: 99%

Voluminous Myoepithelioma of the Minor Salivary Glands Involving the Base of the Tongue

Policarpo

Longoni

Garofalo

et al. 2016

Case Reports in Otolaryngology

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Myoepithelioma is an extremely rare tumour subtype and diagnosis is based on a wide variation of cellular morphology. FNAC specimens do not always suffice for a definitive differential diagnosis which depends on histology and immunohistochemistry of the lesion. Case Presentation. A 54-year-old female came to our attention with dysphagia and dyslalia of 6-month standing. Ear, Nose, and Throat (ENT) examination revealed a voluminous mass on the right portion of the base of her tongue, where postcontrast T2-weighted Magnetic Resonance Imaging (MRI) evidenced a hyperintense lesion. The fine-needle aspiration specimen taken for cytology was not diagnostic, as a differential diagnosis between myoepithelioma and a malignant neoplasm of the salivary glands necessitates parameters that cytology alone cannot provide. Therefore, the whole lesion was excised by diode laser through a transoral approach. Histology and immunohistochemistry of the completely excised lesion confirmed a myoepithelioma.

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Enigma of myoepithelioma at the base of tongue: A rare case report and review of literature

Cited by 5 publications

References 0 publications

Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature

Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature

Clear cell, giant myoepithelioma of tongue base: a diagnostic and surgical challenge

Voluminous Myoepithelioma of the Minor Salivary Glands Involving the Base of the Tongue

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