Enigma of oral potentially malignant disorders - A brief overview

Abstract

Oral cancer is a unique cancer, nevertheless detected at the later stage. It is of note that oral cancer develops from oral potentially malignant disorders (OPMDs) that comprises premalignant lesions and conditions. Dearth of awareness and lack of knowledge in the detection of oral cancer along with patients presenting in the advanced stage of cancer have led to delay in diagnosis. Present treatise consideration will be mainly on the malignant potentiality of rare OPMDs, especially dyskeratosis congenital, epidermolysis bullosa, lupus erythematosus, Plummer-Vinson syndrome, and xeroderma pigmentosum. An English literature search engine was done for articles relating to OPMDs using Medline journals and National Library of Medicine.

Correlation of buccal micronucleus with disease activity score using buccal micronucleus cytome analysis (BMCA) in systemic lupus erythematosus

“…[ 16 ] Up to 5.0% of oral lesions in SLE have been shown to undergo malignant transformation. [ 17 ] Because of the increasing prevalence of SLE in Arab populations, which can be attributed to globalization, it is imperative to devise a simple and clinically applicable chairside screening tool that will provide information about genotoxicity and cytotoxic effects on the oral mucosa.…”

Exploring the Impact of Blood Disorders on Dental Caries

“…People with PVS are more likely to develop fibrosis, and extending these fibrotic areas can cause pain when speaking, eating, or maintaining good dental hygiene. Consequently, they can develop periodontal disease, increased plaque accumulation, cavities, and poor oral hygiene [44][45].…”