2024
DOI: 10.3390/biom14080926
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Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives

Mario García-Domínguez

Abstract: Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems. This review will explore the mechanisms by which enkephalins produce analgesia, emotional regulation, neuroprotection, and other physiological effects. Furthermore, this review will analyze the involvement of enkephalins in the modulation of different pathologies characterized … Show more

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