Enlarged Blind Spots in Chonoretinal Inflammatory Disorders

Reddy, Chittaranjan V.; Brown, Jeremiah; Folk, James C.; Kimura, Alan; Gupta, Sunil; Walker, Jonathan D.

doi:10.1016/s0161-6420(96)30645-3

Cited by 78 publications

(35 citation statements)

References 26 publications

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“…s study had follow-up visual fields and all had normalised by 6 to 47 months). 5 Borruat et al B have described a similar case to ours in which indocyanine green angiography (ICGA) detected an area of peripapillary hypofluorescence that they believed could explain the enlarged blind spot. They concluded that MEWDS is primarily a choroidopathy, in which only the significant lesions manifest funduscopically or on FFA by causing outer retinal involvement and hence dysfunction.…”

Section: Discussionsupporting

confidence: 72%

Peripapillary lesions causing blind spot enlargement in a case of multiple evanescent white dot syndrome

Paul

Gray

1998

Eye

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Section: Discussionsupporting

confidence: 72%

Peripapillary lesions causing blind spot enlargement in a case of multiple evanescent white dot syndrome

Paul

Gray

1998

Eye

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“…We found evidence of bilaterality in only two patients based on ICGA and en face OCT imaging. Previous reports have described bilaterality, 1,4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] although the involvement of the second eye was mild. Li and Kishi 19 performed functional tests such as multifocal electroretinogram and full-field electroretinogram, proving bilateral dysfunction of photoreceptors in most of the MEWDS cases they studied.…”

Section: Discussionmentioning

confidence: 99%

“…To date, at least 22 cases of bilateral involvement have been described with no apparent difference from unilateral cases. 1,4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Secondary choroidal neovascularization has been reported, 23 but only one case was described with choroidal neovascularization secondary to a typical MEWDS clinical presentation. 24 Recurrent episodes (one or more) have also been reported in 12 cases of MEWDS.…”

mentioning

confidence: 99%

Expanded Clinical Spectrum of Multiple Evanescent White Dot Syndrome With Multimodal Imaging

Marsiglia

Gallego-Pinazo

Souza

et al. 2016

Retina

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Purpose: To evaluate and characterize multiple evanescent white dot syndrome abnormalities with modern multimodal imaging modalities.Methods: This retrospective cohort study evaluated fundus photography, fluorescein angiography, indocyanine green angiography, optical coherence tomography, enhanced depth imaging optical coherence tomography, short-wavelength autofluorescence, and near-infrared autofluorescence.Results: Thirty-four multiple evanescent white dot syndrome patients with mean age of 28.7 years were studied (range, 14-49 years). Twenty-six patients were women, and eight were men. Initial mean visual acuity was 0.41 logMAR. Final mean visual acuity was 0.03 logMAR. Fluorescein angiography shows a variable number of mid retinal early fluorescent dots distributed in a wreathlike pattern, which correlate to fundus photography, fundus autofluorescence, and indocyanine green angiography. Indocyanine green angiography imaging shows the dots and also hypofluorescent, deeper, and larger spots, which are occasionally confluent, demonstrating a large plaque of deep retinal hypofluorescence. Optical coherence tomography imaging shows multifocal debris centered at and around the ellipsoid layer, corresponding to the location of spots seen with photography, indocyanine green angiography, and fluorescein angiography. Protrusions of the hyperreflectant material from the ellipsoid layer toward the outer nuclear layer correspond to the location of dots seen with photography, indocyanine green angiography, and fluorescein angiography.Conclusion: Multimodal imaging analysis of the retina in patients with multiple evanescent white dot syndrome shows additional features that may help in the diagnosis of the disease and in further understanding its etiology. Multiple evanescent white dot syndrome is predominantly a disease of the outer retina, centered at the ellipsoid zone, but also involving the interdigitation zone and the outer nuclear layer.RETINA 36: [64][65][66][67][68][69][70][71][72][73][74] 2016

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“…Signifi cant anterior segment infl ammation and mild to moderate vitritis are typically present bilaterally, with whiteyellow lesions (50-500 μm) located in the posterior pole to midperiphery at the level of the RPE. Many authors 28,29 believe these lesions are accompanied by the appearance of turbid subretinal exudation & this diff erentiates SFU from others like MFC & PIC. Meanwhile the active lesions may fade without RPE alterations, get atrophic, or become chorioretinal scars.…”

Section: Sub-retinal Fibrosis and Uveitis Syndromementioning

confidence: 97%