Enlargement of the Inferior Olivary Nucleus in Association With Lesions of the Central Tegmental Tract or Dentate Nucleus

Gautier, J. C.; Blackwood, W.

doi:10.1093/brain/84.3.341

Cited by 98 publications

(53 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Since then, a number of reports describing the clinical, histopathological and MRI findings have been published. [3][4][5][6][7] A variety of insults can lead to hypertrophic olivary degeneration, of which the most commonly reported are haemorrhage, infarct, trauma, surgery or tumour. [8][9][10][11][12][13] The lesions result in loss of synaptic input to the inferior olivary nucleus and in trans-synaptic neuronal degeneration.…”

Section: Resultsmentioning

confidence: 99%

“…14 Histopathologically, it is characterized by neuronal enlargement of the olivary neurons, neuronal loss, vacuolation, demyelination and marked astrogliosis. 3,5,7 It is most often unilateral when it is secondary to a structural lesion, although bilateral changes are recognized 8,15 and may occur if both the superior cerebellar peduncle and the central tegmental tracts are involved. 16,17 Bilateral hypertrophic olivary degeneration has been reported in a few metabolic, genetic, neurodegenerative and toxic disorders.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome

Bindu

Taly²,

Kothari³

et al. 2014

BJR

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome

Bindu

Taly²,

Kothari³

et al. 2014

BJR

View full text Add to dashboard Cite

“…In humans, the IOpr is also a flat ribbon (about 200-300 lm across), with many infoldings. It extends over about 14 mm in the rostral-caudal direction (range, 12-16 mm; Table 3) and is surrounded by a fiber capsule called the ''amiculum olivae'' (Gautier and Blackwood, 1961). The human IOpr is sometimes described as consisting of three lamellae (i.e.…”

Section: Shape and Extent Of The Principal Olivementioning

confidence: 99%

“…This observation is consistent with the finding of NPNFP expression in the IOpr and the link between NPNFP expression and the loss of neurons in the cerebral cortex (Hof et al, 1990;Bussiere et al, 2003). Cerebellar or brainstem damage, specifically to the central tegmental tract, results in a specific type of degeneration in the olive, ''hypertrophic olivary degeneration,'' (Weber, 1942;Gautier and Blackwood, 1961;Goto et al, 1988;Braak et al, 2003;Rü b et al, 2005;Aladdin et al, 2008;Valente et al, 2008). There is also degeneration of IO neurons in several neurological disorders, for example spinocerebellar ataxias and Joubert syndrome (Braak et al, 2003;Rü b et al, 2005;Valente et al, 2008;Popescu et al, 2009).…”

Section: Structure Of the Human Ioprmentioning

confidence: 99%

Neurochemical and Structural Organization of the Principal Nucleus of the Inferior Olive in the Human

Baizer

Sherwood

Hof

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

The inferior olive (IO) is the sole source of the climbing fibers that innervate the Purkinje cells of the cerebellar cortex. The IO comprises several subdivisions, the dorsal accessory olive (DAO), medial accessory olive (MAO), and principal nuclei of the IO (IOpr); the relative sizes of these subnuclei vary among species. In human, there is an expansion of the cerebellar hemispheres and a corresponding expansion of the IOpr. We have examined the structural and neurochemical organization of the human IOpr, using sections stained with cresyl violet (CV) or immunostained for the calcium-binding proteins calbindin (CB), calretinin (CR), and parvalbumin (PV), the synthetic enzyme for nitric oxide (nNOS), and nonphosphorylated neurofilament protein (NPNFP). We found qualitative differences in the folding patterns of the IOpr among individuals and between the two sides of the brainstem. Quantification of IOpr volumes and indices of folding complexity, however, did not reveal consistent left-right differences in either parameter. Single-label immunohistochemistry showed that populations of neurons in the IOpr express CB, CR, NPNFP, and nNOS. Individual fibers labeled for PV, CB, CR, NPNFP, and nNOS were also found. There was individual variability in the numbers and density of stained neurons in the human IOpr; such variability was not seen in other brainstem nuclei. These data are consistent with, and complement, earlier studies showing a dramatic age-related increase in lipofuscin and decrease in RNA in the human IOpr. The impact of these changes in the IOpr on cerebellar function is, however, not known. Anat Rec, 294:1198Rec, 294: -1216Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

show abstract

“…Inferior olivary hypertrophy (IOH) has been reported to be the consequence of damage in the central tegmental tract (Guillain-Mollaret triangle) and to represent a pacemaker for rhythmic hyperkinesias [1,2,3,4,5,6,7]. Such rhythmic hyperkinesias include ocular myoclonus (OM), symptomatic palatal tremor (SPT), and synchronous jerks of limb muscles.…”

Section: Introductionmentioning

confidence: 99%

Inferior Olivary Hypertrophy Is Associated with a Lower Functional State after Pontine Hemorrhage

et al. 2007

View full text Add to dashboard Cite

Background: Inferior olivary hypertrophy (IOH) may develop after pontine hemorrhage and may become a pacemaker for symptomatic palatal tremor (SPT). However, there is no information available that elucidates how IOH may affect the functional outcome. The purpose of this study was to investigate how frequently IOH was associated with clinical manifestations of involuntary movements, including ocular myoclonus (OM) and SPT, and whether IOH influenced the functional outcome after pontine hemorrhage. Methods: In 20 consecutive patients undergoing inpatient multidisciplinary rehabilitation after pontine hemorrhage, the location of lesions (tegmental vs. ventral) and the presence of IOH were examined by magnetic resonance imaging, and the functional outcome was assessed by means of Fugl-Meyer scale for neurological impairment and Functional Independence Measure for disability on admission and discharge. Results: In 10 patients, IOH was detected, and the tegmentum was involved in 7 of the 10 patients. OM or SPT was present in 7 of these 10 patients. In the remaining 10 patients, IOH was not detected, and the tegmentum was involved only in 2 of these 10 patients. None of them had OM or SPT. The presence of IOH was associated with a lower functional status on admission and discharge. Conclusion: After pontine hemorrhage, IOH may be associated with tegmental lesions with OM or SPT and may impose a detrimental effect on the functional outcome.

show abstract

Enlargement of the Inferior Olivary Nucleus in Association With Lesions of the Central Tegmental Tract or Dentate Nucleus

Cited by 98 publications

References 0 publications

Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome

Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome

Neurochemical and Structural Organization of the Principal Nucleus of the Inferior Olive in the Human

Inferior Olivary Hypertrophy Is Associated with a Lower Functional State after Pontine Hemorrhage

Contact Info

Product

Resources

About