Enlisting a Traditional Chinese Medicine to tune the gelation kinetics of a bioactive tissue adhesive for fast hemostasis or minimally invasive therapy

Liquid Copolymers as Biodegradable Surgical Sealant

“…[24] However, for certain deep wound sealing applications, longer gelation times are required in order to fill irregularly shaped wound. [25] At both ratios, the elasticity (G′) of the gels reached values of 10 and 15 kPa, respectively, within 2 min, which is comparable to the shear modulus of soft tissues such as skin and smooth muscles. [26] Overall, the rheological properties suggest suitability of this system as a sealant material: i) the fluidity of the prepolymers (storage modulus lower than 0.1 kPa) enables injection or administration through a wide variety of applicators and procedures (e.g., endoscopic, laparoscopic, or robotic technique); ii) the prepolymers harden quickly and the viscoelastic properties after mixing are dramatically more solid-like and; iii) the formed gels are superior or comparable in terms of their elastic modulus to recently published sealant systems, including those based on fibrin and chitin.…”

Tunable biomaterials for myocardial tissue regeneration: promising new strategies for advanced biointerface control and improved therapeutic outcomes

“…The addition of different concentrations of Borax to the PEG-lysozyme (PEG-LZM) hydrogel allowed modulation of the gelation time from seconds to minutes without causing any change to physical properties. 163 The use of a catheter-based transendocardial delivery technique has received special attention as it is a minimally invasive method and offers control over distribution through multiple injection sites. Intramyocardial injections of hydrogels, on the other hand, are inappropriate for large infarcts whereby multiple injections are required for optimal distribution of the biomaterial.…”

Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

“…In addition, the wound needs a barrier that prevents physical interference and pathogen invasion for proper healing, so applicable tissue adhesion and antibacterial properties are necessary properties of the dressing and also the basic requirements that should be met [ [20] , [21] , [22] , [23] ]. Therefore, designing a wound dressing with biocompatibility and antibacterial performance has recently become a hot topic in modern medicine [ 10 , [24] , [25] , [26] , [27] ]. Among the recently developed dressings, hydrogels with great adhesion, permeability, antibacterial properties, and biocompatibility are considered the most suitable wound dressings [ 9 , 13 , 24 , 28 , 29 ].…”