2019
DOI: 10.3390/vaccines7040122
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Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections

Abstract: Despite medical progress, more than a billion people still suffer daily from parasitic infections. Vaccination is recognized as one of the most sustainable options to control parasitic diseases. However, the development of protective and therapeutic vaccines against tropical parasites has proven to be exceptionally challenging for both scientific and economic reasons. For certain parasitic diseases, traditional vaccine platforms are not well-suited, due to the complexity of the parasite life cycles and the par… Show more

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Cited by 72 publications
(53 citation statements)
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“…Over the last decade, messenger RNA (mRNA) has emerged as a new platform technology for the development of vaccines not just for anti-cancer therapeutics but also against infectious diseases. As reviewed in the accompanying manuscript by Versteeg et al, there is now even progress in the challenging development of mRNA vaccines against parasitic infections where a low-cost and high-throughput vaccine development platform is urgently needed [1].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Over the last decade, messenger RNA (mRNA) has emerged as a new platform technology for the development of vaccines not just for anti-cancer therapeutics but also against infectious diseases. As reviewed in the accompanying manuscript by Versteeg et al, there is now even progress in the challenging development of mRNA vaccines against parasitic infections where a low-cost and high-throughput vaccine development platform is urgently needed [1].…”
Section: Introductionmentioning
confidence: 99%
“…As reviewed elsewhere [1,6], mRNA turns cells into antigen production factories; as vaccines, these antigens trigger potent cellular and humoral immune responses.…”
Section: Introductionmentioning
confidence: 99%
“…Defining clear product development plans that reflect a vaccine strategy that complements existing control programs will be important in the path to developing effective fluke vaccines. In this respect, researchers working in the fluke vaccine space could consider using similar approaches to the burgeoning efforts currently underway with the COVID-19 vaccine pipeline [ 87 ], such as in vitro transcribed mRNA vaccines, a platform recently advocated for the development of neglected parasitic disease vaccines [ 88 ].…”
Section: Discussionmentioning
confidence: 99%
“…Once delivered using an appropriate targeted vaccine delivery system, it can be recognized and internalized by the APCs where the viralderived agents can trigger the innate immune signaling cascades (Fig. 10) 54 .…”
Section: Discussionmentioning
confidence: 99%