Enoxaparin induced eruptive angiokeratoma, an extremely rare side effect

Enoxaparin induced eruptive angiokeratomas

“…In the available literature only three cases of eruptive angiokeratomas induced by enoxaparin were found [3][4][5]. Angiokeratomas are benign vascular lesions with unknown exact etiopathogenesis [3].…”

“…In the available literature only three cases of eruptive angiokeratomas induced by enoxaparin were found [3][4][5]. Angiokeratomas are benign vascular lesions with unknown exact etiopathogenesis [3]. They may arise due to vasoconstriction, downregulation of angiogenic factors and induction of apoptosis of capillary endothelial cells leading to local hyperkeratosis and acanthosis.…”

“…They may arise due to vasoconstriction, downregulation of angiogenic factors and induction of apoptosis of capillary endothelial cells leading to local hyperkeratosis and acanthosis. In case of enoxaparin-induced eruptive angiokeratomas local injury or underlying malformations of the capillary blood vessels were also suggested as a possible explanation [3]. Clinical and dermoscopic findings, if necessary followed by biopsy and a histopathological picture, are the most important factors of the diagnosis [3].…”

“…In case of enoxaparin-induced eruptive angiokeratomas local injury or underlying malformations of the capillary blood vessels were also suggested as a possible explanation [3]. Clinical and dermoscopic findings, if necessary followed by biopsy and a histopathological picture, are the most important factors of the diagnosis [3]. Modification of anticoagulant therapy with discontinuation of enoxaparin, and careful observation of the patient are the first line treatment in the event of an eruptive angiokeratomas induced by enoxaparin [3].…”

“…Clinical and dermoscopic findings, if necessary followed by biopsy and a histopathological picture, are the most important factors of the diagnosis [3]. Modification of anticoagulant therapy with discontinuation of enoxaparin, and careful observation of the patient are the first line treatment in the event of an eruptive angiokeratomas induced by enoxaparin [3]. Physicians should consider this diagnosis when characteristic clinical signs occur shortly after starting enoxaparin treatment.…”