Enoxaparin Prevents Progression of Stages I and II Osteonecrosis of the Hip

Efficiency of iloprost treatment for osseous malperfusion

“…Based on our findings during the past six years, we suggest early therapeutic intervention with iloprost in still reversible ARCO stages I or painful BMO. Other non-surgical treatment strategies for AVN or BMO may include hyperbaric oxygen therapy [16], external electrical stimulation [17], capacitance coupling [18] or the administration of heparin or other anticoagulants [19]. The use of alendronate-a third generation bisphosphonateseems to delay bone collapse by osteoclast inhibition [20].…”

Single US Guided HA Injection Reduced Hip Pain and Improved Function for 20 Months: A Case of Osteonecrosis

“…Currently there are various conservative measures suggested for treatment of ON of the adult hip [7][8][9][10][11][12][13], however the evidence in literature is weak to support their effectiveness in preventing disease progression [20]. A recent review stated that the evidence regarding the conservative treatments for ON is insufficient to make recommendations of any kind, and it can be only considered to gain time to surgery Bilateral osteoarthritis with signs of a vascular necrosis of the proximal femoral epiphysis more evident on the right side.…”

“…In addition to THA and joint preserving procedures [4,5], non-operative management was described in literature [6], this includes drugs such as anticoagulants, bisphospohanates and vasodilators [7][8][9][10] or physical modalities as extra-corporeal shock wave treatment, pulsed electromagnetic therapy, and hyperbaric oxygen [11][12][13]. The results of these different treatment options vary according to diverse factors based on patient and lesion characteristics [14,15].…”

Effect of <i>Qing’e Pill</i> plus <i>Salvia</i> on Non-Traumatic Osteonecrosis of the Femoral Head of Idiopathic Type in Earlier Stage: A Case Report of a Twelve-Month of Period

“…One kind of Hypolipidemics drugs, Simvastatin, will increase the differentiation from marrow stromal cells (MSCs) towards osteoblasts, promoting mineralization of bones while inhibiting the differentiation from MSCs towards adipocytes, which can suggest the prevention of osteonecrosis. However, long-term effective dose of these drugs may bring severe adverse reaction of livers and muscles [10]. Enoxaparin, which is of Anticoagulants, and Iloprost, which is of Vasodilators, can relieve the pain of early-staged primary ONFH patients with tendency of thrombosis and with low fibrinolytic activity, but cannot reverse the necrotic process [11] [12].…”