Enoximone

Dage, Richard C.; Roebel, Lawrence E.; Gibson, John P.; Okerholm, Richard A.; Rolf, Clyde N.

doi:10.1111/j.1527-3466.1986.tb00488.x

Cardiovascular Drug Reviews

1986

DOI: 10.1111/j.1527-3466.1986.tb00488.x

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Enoximone

Richard C. Dage¹,

Lawrence E. Roebel²,

John P. Gibson³

et al.

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1992

2020

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Cited by 3 publications

References 19 publications

(29 reference statements)

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Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization

Hou

2020

Chin. J. Chem.

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Summary of main observation and conclusion An electrochemical synthesis of oxazol‐2‐ones and imidazol‐2‐ones has been developed via 5‐exo‐dig cyclization of propargylic carbamates‐ and ureas‐derived amidyl radicals. The electrosynthesis relies on the dual function of 2,2,6,6‐tetramethylpiperidin‐ 1‐yl)oxyl (TEMPO) as a redox mediator for amidyl radical formation and an oxygen atom donor. The reactions are conducted under mild conditions using a simple setup and provide convenient access to functionalized oxazol‐2‐ones and imidazol‐2‐ones from readily available materials.

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Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization

Hou

2020

Chin. J. Chem.

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Synthesis of Imidazolidin-2-ones and Imidazol-2-ones via Base-Catalyzed Intramolecular Hydroamidation of Propargylic Ureas under Ambient Conditions

et al. 2019

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The first organo-catalyzed synthesis of imidazolidin-2-ones and imidazol-2-ones via intramolecular hydroamidation of propargylic ureas is reported. The phosphazene base BEMP turned out to be the most active organo-catalyst compared with guanidine and amidine bases. Excellent chemo- and regioselectivities to five-membered cyclic ureas have been achieved under ambient conditions, with a wide substrate scope and exceptionally short reaction times (down to 1 min). A base-mediated isomerization step to an allenamide intermediate is the most feasible reaction pathway to give imidazol-2-ones, as suggested by DFT studies.

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Pharmacology of Second Messengers: A Critical Appraisal

Garattini

1992

Drug Metabolism Reviews

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Enoximone

Cited by 3 publications

References 19 publications

Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization

Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization

Synthesis of Imidazolidin-2-ones and Imidazol-2-ones via Base-Catalyzed Intramolecular Hydroamidation of Propargylic Ureas under Ambient Conditions

Pharmacology of Second Messengers: A Critical Appraisal

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