Enregistrement ambulatoire de l'EEG pendant 24 heures dans les spasmes infantiles epileptiques

Plouin, Perrine; Jalin, C; Dulac, Olivier; Chiron, Catherine

doi:10.1016/s0370-4475(87)80068-0

Cited by 16 publications

(2 citation statements)

References 7 publications

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“…WS is usually considered a generalized epilepsy (Commission, 1989), but recent studies point to focal cortical abnormalities. Before or after onset of spasms, patients may exhibit partial epilepsy with a clear focus and selective neuropsychological deficits (Dulac et al, 1987~). Positron emission tomography (PET) studies have shown localized areas of cortical hypometabolism (Chugani et al, 1990) and single photon emission computed tomography (SPECT) studies have shown focal areas of cortical hypoperfusion (Dulac et al, 19876).…”

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confidence: 99%

“…Proponents of secondary involvement cite the high incidence of cortical pathologies in WS (Dulac et al, 1 9 8 7~; Chugani et al, 1990). Clinical data and EEG recordings have shown that partial seizures are associated with spasms in about 50% of symptomatic cases (Plouin et al, 1987). Focal EEG discharges may precede clusters of spasms (Bour et al, 1986;Carrazana et al, 1990;Donat and Wright, 1991).…”

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Study of Regional Cerebral Blood Flow in West Syndrome

et al. 1993

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Focal cortical disturbances are frequent sequelae in West syndrome (WS) even though it is a generalized epileptic syndrome. Functional neuroimaging was used to determine whether focal perfusion abnormalities exist at WS onset and change during evolution. We studied regional cerebral blood flow (rCBF) at different stages of WS. Mean CBF (mCBF) and rCBF were measured using SPECT (single photon emission computed tomography) and 133Xe in 13 WS patients: at onset (20 cases), just after steroids (17 cases), and after a mean follow-up of 2 years (26 cases). At WS onset, interictal mCBF was increased as the result of foci of hyper- and hypoperfusion, which were, respectively, mainly located in the frontal and posterior cortex. Just after steroid therapy, mCBF decreased without any focal predominance. During follow-up, hypoperfused foci remained unchanged whereas the frontal hyperperfused foci decreased after spasm control. Our results show that focal abnormalities are present at WS onset. Focal hypoactivity could reflect a cortical lesion responsible for WS and focal hyperactivity could play a role in the persistence of generalized epilepsy.

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Study of Regional Cerebral Blood Flow in West Syndrome

et al. 1993

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Epileptic encephalopathies in infancy and early childhood

Panayiotopoulos¹

2010

A Clinical Guide to Epileptic Syndromes and Their Treatment

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ten Clinical note Reversible causes for epileptic spasmsDrugs such as theophylline 57 or anti-allergic agents of hista mine H 1 -receptor antagonists, particularly ketotifen, 58 may induce epileptic spasms and hypsar rhythmia that are entirely reversible upon drug withdrawal.Pyridoxine dependency, which is treatable, can in rare instances present with epileptic spasms. This is most likely when other seizure types have occurred before the onset of spasms. 46 AetiologyThe aetiology is multiple and diverse. Aetiologically, West syndrome is classified, in order of preva lence, as symptomatic (about 80% of all) due to discernible organic insults, and cryptogenic or idiopathic

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Infantile spasms combined with partial seizures: electroclinical study of eleven cases

Viani¹,

Romeo²,

Mastrangelo

et al. 1994

Ital J Neuro Sci

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We studied 11 infants (7 males) with combined infantile spasms (IS) and partial seizures. The age of onset of the spasms ranged from 6 days to 9 months. All of the children had neurological or CT/MRI abnormalities, and five also had a family history of epilepsy. The clinical and polygraphic patterns of the clusters of spasms combined with partial seizures were analysed. Ten infants were followed-up for a mean period of 3 years, 4 months (range 1 year 10 months to 4 years 11 months). At the last check-up, the seizures were controlled in 2 patients; the others continued to have spasms and/or partial seizures. All of the patients developed mild to severe psychomotor retardation. This condition defines a subgroup of infants presenting with IS, which is distinct from West syndrome.

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Enregistrement ambulatoire de l'EEG pendant 24 heures dans les spasmes infantiles epileptiques

Cited by 16 publications

References 7 publications

Study of Regional Cerebral Blood Flow in West Syndrome

Study of Regional Cerebral Blood Flow in West Syndrome

Epileptic encephalopathies in infancy and early childhood

Infantile spasms combined with partial seizures: electroclinical study of eleven cases

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