Enriched environment and exercise effects on parvalbumin expression and distribution in the hippocampal formation of developing rats

Serra, Fernando Tadeu; Araújo, Bruno Henrique Silva; Placencia, Eduardo Varejão Díaz; Henrique, Jéssica Salles; Doná, Flávia; Torres, Laila Brito; Fernandes, María José da Silva; Arida, Ricardo Mário; Silva, Sérgio Gomes da

doi:10.1016/j.brainresbull.2020.03.021

Cited by 5 publications

(14 citation statements)

References 30 publications

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“…(2018) Rat (Wistar) Adult Adult ♂ EE 2 months Dentate Gyrus IHC Total PV cell number no change [149] Sampedro-Piquero et al. (2016) Rat (Wistar) Juvenile Adult ♂ EE 40 days Dentate Gyrus IHC PV cell density no change [154] Serra et al. (2020) Rat (Wistar) Juvenile Adult ♂ Exercise 40 days Dentate Gyrus IHC PV cell density increased [154] Serra et al.…”

Section: Resultsmentioning

confidence: 99%

“…(2016) Rat (Wistar) Juvenile Adult ♂ EE 40 days Dentate Gyrus IHC PV cell density no change [154] Serra et al. (2020) Rat (Wistar) Juvenile Adult ♂ Exercise 40 days Dentate Gyrus IHC PV cell density increased [154] Serra et al. (2020) Rat (Sprague-Dawley) Adolescent Adolescent ♂ R- or S-ketamine 10 mg/kg IP; sacrifice 30 min later Dentate Gyrus IHC PV cell density decreased by S-ketamine [186] Yang et al.…”

Section: Resultsmentioning

confidence: 99%

“…(2018) Rat (Wistar) Juvenile-adolescent Adult ♂ Physical exercise 40 days CA2/3 IHC Total PV cell number increased [58] Gomes da Silva et al., 2010 Rat (Long-Evans) Adult Adult ♂ Physical exercise 30 min/day for 5 weeks CA2/3 IHC Total PV cell number increased [121] Nguyen et al. (2013) Rat (Wistar) Juvenile Adult ♂ EE 40 days CA2/3 IHC PV cell density no change [154] Serra et al. (2020) Rat (Wistar) Juvenile Adult ♂ Exercise 40 days CA2/3 IHC PV cell density increased [154] Serra et al.…”

Section: Resultsmentioning

confidence: 99%

“…(2013) Rat (Wistar) Juvenile Adult ♂ EE 40 days CA2/3 IHC PV cell density no change [154] Serra et al. (2020) Rat (Wistar) Juvenile Adult ♂ Exercise 40 days CA2/3 IHC PV cell density increased [154] Serra et al. (2020) Tree Shrew (Tupaia Belangeri) Adult Adult ♂ 5 weeks' daily psychosocial conflict; FLX (15 mg/kg/day) or SLV-323 (20 mg/kg/day) oral treatment daily for latter 4 weeks CA3 IHC Total PV cell number Decreased by stress; rescued by SLV-323 [31] Czeh et al.…”

Section: Resultsmentioning

confidence: 99%

“…(2013) PV-Cre mice Adult Adult ♂ EE Dorsal CA3b Chemogenetic activation of PV cells; IHC fraction of PV cells expressing high amounts of PV increased [36] Donato et al. (2013) Rat (Wistar) Juvenile Adult ♂ EE 40 days Subiculum IHC PV cell density no change [154] Serra et al. (2020) Rat (Wistar) Juvenile Adult ♂ Exercise 40 days Subiculum IHC PV cell density increased [154] Serra et al.…”

Section: Resultsmentioning

confidence: 99%

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Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

Perlman¹,

Tanti²,

Mechawar³

2021

Neurobiology of Stress

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Stress-related psychiatric disorders including depression involve complex cellular and molecular changes in the brain, and GABAergic signaling dysfunction is increasingly implicated in the etiology of mood disorders. Parvalbumin (PV)-expressing neurons are fast-spiking interneurons that, among other roles, coordinate synchronous neuronal firing. Mounting evidence suggests that the PV neuron phenotype is altered by stress and in mood disorders. In this systematic review, we assessed PV interneuron alterations in psychiatric disorders as reported in human postmortem brain studies and animal models of environmental stress. This review aims to 1) comprehensively catalog evidence of PV cell function in mood disorders (humans) and stress models of mood disorders (animals); 2) analyze the strength of evidence of PV interneuron alterations in various brain regions in humans and rodents; 3) determine whether the modulating effect of antidepressant treatment, physical exercise, and environmental enrichment on stress in animals associates with particular effects on PV function; and 4) use this information to guide future research avenues. Its principal findings, derived mainly from rodent studies, are that stress-related changes in PV cells are only reported in a minority of studies, that positive findings are region-, age-, sex-, and stress recency-dependent, and that antidepressants protect from stress-induced apparent PV cell loss. These observations do not currently translate well to humans, although the postmortem literature on the topic remains limited.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

Perlman¹,

Tanti²,

Mechawar³

2021

Neurobiology of Stress

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Environmental and neurodevelopmental contributors to youth mental illness

Whittle,

Zhang,

Rakesh

2024

Neuropsychopharmacol.

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While a myriad of factors likely contribute to the development of mental illness in young people, the social environment (including early adverse experiences) in concert with neurodevelopmental alterations is undeniably important. A number of influential theories make predictions about how and why neurodevelopmental alterations may mediate or moderate the effects of the social environment on the emergence of mental illness. Here, we discuss current evidence supporting each of these theories. Although this area of research is rapidly growing, the body of evidence is still relatively limited. However, there exist some consistent findings, including increased striatal reactivity during positive affective processing and larger hippocampal volumes being associated with increased vulnerability or susceptibility to the effects of social environments on internalizing symptoms. Limited longitudinal work has investigated neurodevelopmental mechanisms linking the social environment with mental health. Drawing from human research and insights from animal studies, we propose an integrated mediation-moderation model and outline future research directions to advance the field.

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Renal claudin-14 expression is not required for regulating Mg²⁺ balance in mice

Ferreira

Megen

Tan

et al. 2021

American Journal of Physiology-Renal Physiology

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The kidneys play a crucial role in maintaining calcium (Ca2+) and magnesium (Mg2+) homeostasis by regulating these minerals' reabsorption. In the thick ascending limb of Henle's loop (TAL), Ca2+ and Mg2+ are reabsorbed through the tight junctions by a shared paracellular pathway formed by claudin-16 and claudin-19. Hypercalcemia activates the Ca2+-sensing receptor (CaSR) in the TAL, causing upregulation of the pore-blocking claudin-14 (CLDN14) that reduces Ca2+ and Mg2+ reabsorption from this segment. Additionally, a high Mg2+ diet is known to increase both urinary Mg2+ and Ca2+ excretion. Since Mg2+ may also activate the CaSR, we aimed to investigate whether CaSR-dependent increases in CLDN14 expression also regulate urinary Mg2+ excretion in response to hypermagnesemia. Here we show that a Mg2+-enriched diet increased urinary Mg2+ and Ca2+ excretion in mice, however this occurred without detectable changes in renal CLDN14 expression. The administration of a high Mg2+ diet to Cldn14-/- mice did not cause more pronounced hypermagnesemia nor significantly alter urinary Mg2+ excretion. Finally, in vitro evaluation of CaSR-driven Cldn14 promoter activity in response to increasing Mg2+ concentrations revealed that Cldn14 expression only increases at supraphysiological extracellular Mg2+ levels. Together, these results suggest that CLDN14 is not involved in regulating extracellular Mg2+ balance following high dietary Mg2+ intake.

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Enriched environment and exercise effects on parvalbumin expression and distribution in the hippocampal formation of developing rats

Cited by 5 publications

References 30 publications

Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

Environmental and neurodevelopmental contributors to youth mental illness

Renal claudin-14 expression is not required for regulating Mg²⁺ balance in mice

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Enriched environment and exercise effects on parvalbumin expression and distribution in the hippocampal formation of developing rats

Cited by 5 publications

References 30 publications

Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

Environmental and neurodevelopmental contributors to youth mental illness

Renal claudin-14 expression is not required for regulating Mg2+ balance in mice

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Product

Resources

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Renal claudin-14 expression is not required for regulating Mg²⁺ balance in mice