ENT manifestation in COVID-19 patients

El‐Anwar, Mohammad Waheed; Elzayat, Saad; Fouad, Yasser Ahmed

doi:10.1016/j.anl.2020.06.003

Cited by 115 publications

(143 citation statements)

References 18 publications

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“…The most common otolaryngologic symptom was odynophagia (63.5%) followed by smell and taste abnormality (n = 45, overall-20%, 46.8% of all ENT symptoms). Pharyngeal symptoms were found to be more commonly associated with COVID-19 than nasal symptoms like obstruction and discharge in studies from Italy and Egypt [5,6]. The smell and taste disturbance was found to be temporary with 96% of the patients regaining their function by 4 weeks.…”

Section: Discussionmentioning

confidence: 93%

Otolaryngologic Manifestation and Long-Term Outcome in Mild COVID-19: Experience from a Tertiary Care Centre in India

Panda

Mohamed

Sikka

et al. 2020

Indian J Otolaryngol Head Neck Surg

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This study endeavours to comprehensively the study the spectrum of ENT manifestations in mild and asymptomatic COVID-19 and observe the natural course of anosmia and dysgeusia consequent to SARS-Cov-2 infection. A prospective cohort study was undertaken at a tertiary care centre in India on admitted patients with RT-PCR proven COVID-19. Patients were included provided the baseline National Early Warning Score (NEWS) was less than 4. Patients were screened for ENT manifestations using a questionnaire at baseline, 7 days, 14 days and 28 days. 225 patients were included in the study. Of these complete data at 4 weeks was available for 210. Out of 145 patients with mild COVID-19 (asymptomatic = 80), ENT manifestations accounted for 66.2% of all symptoms. Smell and taste disturbance had an overall incidence of 20% and 45% of ENT manifestations. Temporal trends of the recovery rate of anosmia and dysgeusia were 53.6% and 66.7% at 2 weeks, respectively. Corresponding rates at 3 weeks were 89.29% and 86.7%, respectively. By the end of 4 weeks 96% of the patients had recovered completely. The incidence of anosmia and dysgeusia in this study parallels the rates reported from other Asian countries, albeit, lower than the rates quoted from the Western Hemisphere. We recommend structured reporting of all ENT manifestations especially smell and taste disturbances to accurately identify individuals infected with SARS-Cov-2.

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Section: Discussionmentioning

confidence: 93%

Otolaryngologic Manifestation and Long-Term Outcome in Mild COVID-19: Experience from a Tertiary Care Centre in India

Panda

Mohamed

Sikka

et al. 2020

Indian J Otolaryngol Head Neck Surg

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“…The reported frequency of headache in a recent meta-analysis was 12% of patients [5], ranging from 6.5% [6] to 70.3% [7] depending on the studies, with most of the studies reporting a frequency within 10-30% of patients [8,9]. Headache might be caused by the release of cytokines, endothelial damage and macrophage activation; or it could be related to the inflammation of lymphatic structures, as the lymphatic organs located in the naso-and oropharynx around the Waldeyer's ring [10,11]. The real causes of headache in COVID-19 are still uncertain.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

et al. 2020

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Introduction: Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality. Methods: Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis. Results: During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17-0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer. Conclusion: Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.

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“…Prior coronavirus epidemics in 2002 and 2012 presented with predominantly with lower respiratory tract symptoms such as cough, shortness of breath and fever and could progress rapidly to acute respiratory distress syndrome (ARDS). SARS-CoV-2 infection has been found to present commonly with both lower respiratory tract symptoms such as fever, cough, shortness of breath, ARDS as well as upper respiratory tract symptoms such as loss of sense of taste and smell [4]. Otalgia and hearing loss have been reported very rarely [5].…”

Section: Introductionmentioning

confidence: 99%

“…We present a case of upper respiratory tract infection with involvement of the sinuses and middle ear secondary COVID-19 infection due to SARS-CoV-2. smell [4,7]. Involvement of the middle ear and sinuses from upper respiratory tract infection with SARS-CoV-2 has been previously reported in a very small number of case reports [5].…”

Section: Introductionmentioning

confidence: 99%

Recent Hearing Loss and Earache due to Bilateral Otitis Media associated with SARS-CoV-2 infection

Ilyas¹,

Bathula²

2020

Arch Otolaryngol Rhinol

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Background: Since the outbreak began in late December 2019, COVID-19 has been declared a global pandemic, with over 3 million cases reported worldwide. COVID-19 is known to present commonly with symptoms such as fever, cough, shortness of breath, myalgias, loss of sense of taste and smell. Otalgia and hearing loss have been reported very rarely. We present a case of upper respiratory tract infection with involvement of the sinuses and middle ear secondary to SARS-CoV-2 infection. Case report: A 69-year-old woman presented with fever, productive cough, bilateral earache, and diminished hearing for 5 days prior to admission. On examination, her temperature was 38.2 C, respirations 22/min, pulse rate 112/min, with O2 saturation of 96%. Otoscopy revealed erythema and opacifi cation of the left tympanic membrane suggestive of otitis media. SARS-CoV-2 infection was confi rmed by reverse transcription-polymerase chain reaction (RT-PCR) testing from nasopharyngeal swab. Chest x-ray revealed vascular congestion but no parenchymal opacities. A diagnosis of upper respiratory infection due to SARS-CoV-2 involving the sphenoid sinus and both middle ears was made based on head CT scan. Conclusion: COVID-19 most commonly presents with fever and respiratory symptoms, including cough, shortness of breath, anosmia, hyposmia, dysgeusia and sore throat. Involvement of the ear and sinuses from upper respiratory tract infection with SARS-CoV-2 has been previously reported in very limited case reports. We are presenting this case because we believe these fi ndings should possibly alert clinicians to suspect SARS-CoV-2 infection and take proper protective measures to prevent the spread of infection.

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ENT manifestation in COVID-19 patients

Cited by 115 publications

References 18 publications

Otolaryngologic Manifestation and Long-Term Outcome in Mild COVID-19: Experience from a Tertiary Care Centre in India

Otolaryngologic Manifestation and Long-Term Outcome in Mild COVID-19: Experience from a Tertiary Care Centre in India

Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

Recent Hearing Loss and Earache due to Bilateral Otitis Media associated with SARS-CoV-2 infection

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