Entamoeba Histolytica, Antigens and Amoebiasis

Chayen, Ann; Avron, Boaz

doi:10.1007/978-3-662-09197-5_3

Cited by 2 publications

(1 citation statement)

References 128 publications

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“…In addition, a few our detected biological processes and functions are also associated with virus infection [40–42], such as HRV infection, as discovered in Table 1 (Noted, the metagene id in this table will be used to label the corresponding pathway in following figures for convenience). For example, the transient receptor potential (TRP) channel family are potential candidates for sensing physical and chemical stimuli, and TRP channels +may be novel therapeutic targets for controlling virus-induced cough [43]; Amoebiasis, the condition of harbouring the protozoan parasite Entamoebahistolytica, is a major health problem throughout the world [44], and parasite virulence can implicate multiple amoebic and host factors through complex host-parasite interactions [45]; and HCV infection is able to induce autophagy and downstream UPR molecules regulating key autophagic gene expression, which just can similarly promote human rhinovirus infection via the autophagic pathway [46, 47].…”

Section: Resultsmentioning

confidence: 99%

Dynamically characterizing individual clinical change by the steady state of disease-associated pathway

Sun

et al. 2019

BMC Bioinformatics

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BackgroundAlong with the development of precision medicine, individual heterogeneity is attracting more and more attentions in clinical research and application. Although the biomolecular reaction seems to be some various when different individuals suffer a same disease (e.g. virus infection), the final pathogen outcomes of individuals always can be mainly described by two categories in clinics, i.e. symptomatic and asymptomatic. Thus, it is still a great challenge to characterize the individual specific intrinsic regulatory convergence during dynamic gene regulation and expression. Except for individual heterogeneity, the sampling time also increase the expression diversity, so that, the capture of similar steady biological state is a key to characterize individual dynamic biological processes.ResultsAssuming the similar biological functions (e.g. pathways) should be suitable to detect consistent functions rather than chaotic genes, we design and implement a new computational framework (ABP: Attractor analysis of Boolean network of Pathway). ABP aims to identify the dynamic phenotype associated pathways in a state-transition manner, using the network attractor to model and quantify the steady pathway states characterizing the final steady biological sate of individuals (e.g. normal or disease). By analyzing multiple temporal gene expression datasets of virus infections, ABP has shown its effectiveness on identifying key pathways associated with phenotype change; inferring the consensus functional cascade among key pathways; and grouping pathway activity states corresponding to disease states.ConclusionsCollectively, ABP can detect key pathways and infer their consensus functional cascade during dynamical process (e.g. virus infection), and can also categorize individuals with disease state well, which is helpful for disease classification and prediction.

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Section: Resultsmentioning

confidence: 99%

Dynamically characterizing individual clinical change by the steady state of disease-associated pathway

Sun

et al. 2019

BMC Bioinformatics

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Biochemistry of Entamoeba: A review

Avron

Chayen

1988

Cell Biochemistry & Function

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Entamoeba histolytica, the protozoan parasite causing amoebiasis, is carried by approximately 10% of the world's population although only a minority of carriers of the organism present active clinical symptoms.Although Entamoeba are classified as eukaryotes, the biochemistry of these organisms has a number of unusual facets which are reminiscent of prokaryotes. It has indeed been suggested that these cells represent early evolutionary forms that have been successful in surviving unchanged in the protected environment in which they reproduce (the intestine).Glycolysis in Entarnoeba lacks several of the typical eukaryotic glycolytic enzymes. The pentose phosphate shunt enzymes are missing completely. Another unusual feature of the glycolytic path is the utilization of PP, instead of ATP in a number of enzyme reactions e.g. phosphofructokinase. Entamoeba is the only eukaryote in which one of these PP, utilizing enzymes, phosphoenolpyruvate carboxytransferase, has been found.The respiratory pathway is also an unusual one. Entamoeba are classified as anaerobes but the cells do have an affinity for oxygen. The oxygen is reduced to water at the end of a respiratory chain which is not well understood but which operates withough cytochromes or mitochondria.The nucleic acid, protein and lipid metabolic pathways have not been well studied and interest has mainly focused on the proteolytic processes of the amoeba which have been implicated in the pathogenic, histolytic behavior of the parasite. Despite these efforts the mechanism of attack of the parasite and the stimuli that cause it to invade the host are not yet clear. This understandably is the goal of much of the present studies concerning E. histolytica but the organism also deserves study in its own right as an example of an organism that has an unusual biochemistry and may represent an early stage in the evolution of eukaryotic cells.

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Entamoeba Histolytica, Antigens and Amoebiasis

Cited by 2 publications

References 128 publications

Dynamically characterizing individual clinical change by the steady state of disease-associated pathway

Dynamically characterizing individual clinical change by the steady state of disease-associated pathway

Biochemistry of Entamoeba: A review

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