Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

Dong, Yujiao; Paukkonen, Heli; Fang, Wenwen; Laaksonen, Timo; Laaksonen, Päivi

doi:10.1016/j.ijpharm.2018.06.022

Cited by 22 publications

(15 citation statements)

References 35 publications

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“…In agreement with previous high-pressure treatment studies (Pääkkö et al 2007;Iotti et al 2011;Charani et al 2013;Dimic-Misic et al 2018;Dong et al 2018), both G' and G'' increased with higher cellulose hydrogel consistency. The hydrogels with higher consistencies produced more concentrated gels that subsequently led to the increase in modulae.…”

Section: Fig 4 Wrv For Celraw Materials MCC and Produced Cellulose Hydrogelssupporting

confidence: 92%

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Manufacturing of hydrogels from never-dried microcrystalline cellulose by high-pressure mechanical treatment

Lähdeniemi

Vanhatalo

Dahl

2021

BioRes

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Microcrystalline cellulose-based hydrogels were made using never-dried MCC (AaltoCellTM) as a raw material for a high-pressure mechanical treatment consisting of one to five passes at 700 bars. The effects of the mechanical treatment on the crystalline structure, morphology, geometrical dimensions, and specific surface area as well as rheological properties of the manufactured cellulose gel product were investigated. The results indicated that the process detached part of the crystalline area of the cellulose, resulting in loose particle architecture, increased surface area and porosity, and thus more accessible and reactive material. Due to the creation of the new internal surface area and porosity, more hydrogen bonds were formed between the cellulose particles, consequently creating more stable cellulose hydrogel-like slurries. The properties of the produced hydrogels were greatly influenced by the number of the treatment passes through the process equipment. Several passes through the process produced stronger cellulose hydrogels capable of retaining more water.

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Section: Fig 4 Wrv For Celraw Materials MCC and Produced Cellulose Hydrogelssupporting

confidence: 92%

“…The most important references for this study are Dimic-Misic et al (2018) and Dong et al (2018), as both of them used the same raw material: never-dried MCC made with the AaltoCell TM procedure. These studies are in good accordance with each other.…”

Section: Fig 4 Wrv For Celraw Materials MCC and Produced Cellulose Hydrogelsmentioning

confidence: 99%

Manufacturing of hydrogels from never-dried microcrystalline cellulose by high-pressure mechanical treatment

Lähdeniemi

Vanhatalo

Dahl

2021

BioRes

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“…The release behaviours by the CNF shells were faster and more pH-selective than those of spray-dried CNF microparti- cles 33 or CNF-reinforced alginate microspheres, 34 likely because of the good dispersibility and well-defined structure of our microparticles. Generally, CNF gels show slow and sustained drug release properties over a period of several days 35,36 or months, 33,37 because the dense CNF network structure decreases the diffusivity of drug molecules. Although the CNFshells in this work did not show the slow and long-lasting release properties, this material showed unique pH-triggered release properties and good dispersibility with small sizes.…”

mentioning

confidence: 99%

Fabrication of ultrathin nanocellulose shells on tough microparticlesviaan emulsion-templated colloidal assembly: towards versatile carrier materials

et al. 2019

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“…In the literature, it is suggested a potential use of cellulose hydrogel for application and release molecules, where this release can be controlled through ultrasonic treatments [35]. Previous study with cellulose microcrystals concluded that low molecular weight molecules and drugs were faster released when compared with molecules with high molecular weight [36].…”

Section: Release Of Nisin From N-cbmentioning

confidence: 99%

Nisin-Loaded Bacterial Cellulose: Evaluation of Its Antimicrobial Activity Stability

Santos¹,

Soeiro²,

Ataide³

et al. 2020

Preprint

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Nisin is a 3.4 kDa antimicrobial peptide, produced by Lactococcus lactis (ATCC 11454). This bacteriocin can inhibit spores gemination and gram-positive bacteria development and has gained visibility in therapeutic use. The bacterial cellulose (CB) has been considered an ideal material and with high quality applied in food and medical-pharmaceutical inputs. Because of all this benefits, it is important to know the system proceeding of CB with nisin. Therefore, it was realize nisin release profile analysis of CBs was performed; analysis of the minimum inhibitory concentration (MIC) of nisin against Escherichia coli ATCC 25922, Pseudomonas aeuroginosa ATCC 9721 and Staphylococus aureus ATCC 10390; antimicrobial stability test, for 100 days at different temperatures of 4º, 25º and 37 ° C against microorganisms: S. aureus e L. sakei. The results show that nisin is released by the CB in 4 hours of contact with medium and the MIC of nisin is 78 µg/mL for S. aureus, doesn’t have gram-negative inhibition. It had stability until 100 days against L. sakei and 60 days for S. aureus. The system proved to be efficient and CB potentiated the antimicrobial action of nisin, acting as a selective barrier for other compounds present in the standard solution, serving as protection of the peptide at different temperatures. The CB loading system can be an ideal antimicrobial stability system for nisin.

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Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

Cited by 22 publications

References 35 publications

Manufacturing of hydrogels from never-dried microcrystalline cellulose by high-pressure mechanical treatment

Manufacturing of hydrogels from never-dried microcrystalline cellulose by high-pressure mechanical treatment

Fabrication of ultrathin nanocellulose shells on tough microparticlesviaan emulsion-templated colloidal assembly: towards versatile carrier materials

Nisin-Loaded Bacterial Cellulose: Evaluation of Its Antimicrobial Activity Stability

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