This study explores the thermal quantum-memory-assisted entropic uncertainty relation (QM-EUR) and entanglement in a general two-qubit XYZ-Heisenberg spin chain model in the presence of the Dzyaloshinskii-Moriya (DM) interaction. The characterization of y-component DM and spin-spin interactions are particularly focused. It is found that the DM and spin-spin interaction strengths highly regulate the flow behavior and the initial final levels of QM-EUR and entanglement. In comparison, the spin-spin interaction strength in the z-direction remains useful in both ferromagnetic and anti-ferromagnetic regimes for entropic uncertainty suppression and entanglement generation. Additionally, the negative and the positive y-directed DM values can usefully turn classical states into resourceful quantum states. The dynamics of thermal QM-EUR and entanglement-of-formation have symmetric behaviors only with respect to y-component DM and z-component spin-spin interaction. Finally, different critical points of temperature, y-component DM as well as spin-spin interaction are encountered, which should be opted to preserve quantum correlations and degrade uncertainty.