Entendendo o conceito PIRO: da teoria à prática clínica - Parte 1

Abstract

Despite recent advances in diagnosis and care of critically ill patients sepsis related mortality rate remains unacceptably high. Therefore, new methods of evaluation are necessary to provide an earlier and more accurate characterization of septic patients. Based on the (oncologic) TNM system, the PIRO concept was introduced as a new staging system for sepsis in order to assess risk and predict prognosis, with potential to assist in inclusion of patients in clinical studies and estimate the probability of response of patients to specific therapeutic interventions.

Proteomic updates on sepsis

“…Another important reference to assess patients with sepsis is the PIRO concept, which is substantiated on multivariate elements, including predisposing conditions, insult quality and range, type and magnitude of the host response (deleterious response), and resulting or preexisting organic dysfunction (organic failure) 46 . The PIRO concept is interesting to rate septic patients, aiming at the development of studies to understand the physiopathology and improve therapeutics 47 .…”

Sepse: atualidades e perspectivas

“…(35) Another important assessment tool for septic patients is the PIRO concept, based on several elements which include predisposition (P), injury (I), host response (R) and organ failure (O). (36) The PIRO concept is useful for categorizing septic patients to develop studies both to better understand the pathophysiology and to improve therapeutics. (37)…”

Use of biomarkers in pediatric sepsis: literature review

“…(6) Sepsis staging into these four domains allows stratification of its treatment by individualizing the treatment used in each domain. (7) The host response to infection is known to be variable and individual, involving increased levels of biomarkers and biomediators that participate in the inflammatory response to the infectious insult. The specific response of any patient depends on the focus of infection, the pathogen causing the infection, and the host (genetic predisposition and coexisting diseases), and different responses occur at the local, regional, and systemic levels.…”