Enteral and Parenteral Nutrition: An Integrative Literature Review on Nutrition in Pediatric Recipients of Hematopoietic Stem Cell Transplantation

Woods, Theresa; Tariman, Joseph D.; Lee, Young-Me

doi:10.1188/19.cjon.351-354

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…PN is traditionally used during HSCT [156]. However, increasing evidence has demonstrated that EN leads to better post-transplant outcomes, such as reduced overall survival, infection and aGVHD [155,[157][158][159][160]. PN results in the loss of commensal bacteria and reduces the levels of SCFAs [26,161], while EN promotes the recovery of gut microbial diversity and restoration of SCFA-producing bacteria [161,162].…”

Section: Othersmentioning

confidence: 99%

Roles of the intestinal microbiota and microbial metabolites in acute GVHD

Lin

et al. 2021

Exp Hematol Oncol

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most curative strategies for the treatment of many hematologic malignancies and diseases. However, acute graft-versus-host disease (GVHD) limits the success of allo-HSCT. The prevention and treatment of acute GVHD is the key issue for improving the efficacy of allo-HSCT and has become a research hotspot. The intestine is the primary organ targeted by acute GVHD, and the intestinal microbiota is critical for maintaining the homeostasis of the intestinal microenvironment and the immune response. Many studies have demonstrated the close association between the intestinal microbiota and the pathogenesis of acute GVHD. Furthermore, dysbiosis of the microbiota, which manifests as alterations in the diversity and composition of the intestinal microbiota, and alterations of microbial metabolites are pronounced in acute GVHD and associated with poor patient prognosis. The microbiota interacts with the host directly via microbial surface antigens or microbiota-derived metabolites to regulate intestinal homeostasis and the immune response. Therefore, intervention strategies targeting the intestinal microbiota, including antibiotics, prebiotics, probiotics, postbiotics and fecal microbiota transplantation (FMT), are potential new treatment options for acute GVHD. In this review, we discuss the alterations and roles of the intestinal microbiota and its metabolites in acute GVHD, as well as interventions targeting microbiota for the prevention and treatment of acute GVHD.

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Section: Othersmentioning

confidence: 99%

Roles of the intestinal microbiota and microbial metabolites in acute GVHD

Lin

et al. 2021

Exp Hematol Oncol

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“…However, the clinical benefits of PN in patients receiving high-dose chemotherapy during HSCT are unknown [ 5 , 6 ]. An integrative review on the efficacy of enteral nutrition and PN for meeting the nutrition and energy needs of pediatric patients following HSCT was published in 2019 [ 7 ]. More recently, the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) reported the resulting consensus on the management of sinusoidal obstructive syndrome, mucositis, enteral and parenteral nutrition, iron overload, and emesis during HSCT [ 8 ], as well as on prevention of infections [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have revised the effects of PN in children with HSCT [ 3 , 4 , 7 ]. However, only a few addressed the question of the potential effects of enriched FO lipid emulsions compared with standard lipid emulsions [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

The Metabolic Impact of Two Different Parenteral Nutrition Lipid Emulsions in Children after Hematopoietic Stem Cell Transplantation: A Lipidomics Investigation

Rangel-Huerta

Torre-Aguilar

Mesa

et al. 2022

IJMS

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Hematopoietic stem cell transplantation (HSCT) involves the infusion of either bone marrow or blood cells preceded by toxic chemotherapy. However, there is little knowledge about the clinical benefits of parenteral nutrition (PN) in patients receiving high-dose chemotherapy during HSCT. We investigated the lipidomic profile of plasma and the targeted fatty acid profiles of plasma and erythrocytes in children after HSCT using PN with either a fish oil-based lipid emulsion or a classic soybean oil emulsion. An untargeted liquid chromatography high-resolution mass spectrometry platform connected with a novel in silico annotation algorithm was utilized to determine the most relevant chemical subclasses affected. In addition, we explored the interrelation between the lipidomics profile in plasma, the targeted fatty acid profile in plasma and erythrocytes, several biomarkers of inflammation, and antioxidant defense using an innovative data integration analysis based on Latent Components. We observed that the fish oil-based lipid emulsion had an impact in several lipid subclasses, mainly glycerophosphocholines (PC), glycerophosphoserines (PS), glycerophosphoethanolamines (PE), oxidized PE (O-PE), 1-alkyl,2-acyl PS, lysophosphatidylethanolamines (LPE), oxidized PS (O-PS) and dicarboxylic acids. In contrast, the classic soybean oil emulsion did not. Several connections across the different blocks of data were found and aid in interpreting the impact of the lipid emulsions on metabolic health.

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