Enteral feeding of preterm neonates: a survey of Australian neonatologists

Patole, Sanjay; Müller, Reinhold

doi:10.1080/jmf.16.5.309.314

Cited by 30 publications

(18 citation statements)

References 26 publications

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“…5,[10][11][12] Precipitous advancement of EN might predispose to necrotizing enterocolitis (NEC). 13 Conversely, delays in the initiation of enteral nutrition increase the risk for sepsis and nutritional deficiencies.…”

Section: Discussionmentioning

confidence: 99%

Earlier initiation of enteral nutrition is associated with lower risk of late-onset bacteremia only in most mature very low birth weight infants

Lavoie

2009

J Perinatol

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Objective: To examine the temporal relationship between early enteral nutrition (EN) and coagulase-negative staphylococcal (CoNS)-related lateonset bacteremia (LOB) in very low birth weight (VLBW) neonates.Study Design: Multivariate analyses performed on a large retrospective cohort of neonates admitted to a tertiary care neonatal unit.Results: Due to the predominance and particular timing of CoNS, LOB occurred mostly during a critical period peaking at 9 days of age. This period also corresponded to a gestational maturation-dependent breakpoint in time to achieve full EN, associated with significant reduction in incidence of bacteremia (adjusted OR 0.15; 95%CI [0.10-0.20]; P<0.05). In subgroup analyses, more 'mature' (i.e. X28 and <32 weeks) preterm neonates reached full EN before this critical period and consequently, earlier EN in this group was associated with a shorter duration of PN and reduced incidence of CoNS bacteremia. In contrast, most 'immature' preterm neonates (i.e. <28 weeks) generally received PN beyond this critical period and therefore, did not appear to benefit from earlier initiation of EN. Even though EN was usually initiated earlier when formula milk was used as a complement to breast-milk, this practice was not associated with a reduction in the incidence of CoNS in any preterm gestational groups tested. Conclusion:A reduction in incidence of bacteremia was observed only in more mature VLBW neonates who achieved full EN before the secondweek of life critical period for CoNS, These results provide important endpoints for future trials evaluating changes in nutritional interventions potentially effective in reducing neonatal LOB.

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Section: Discussionmentioning

confidence: 99%

Earlier initiation of enteral nutrition is associated with lower risk of late-onset bacteremia only in most mature very low birth weight infants

Lavoie

2009

J Perinatol

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“…Enteral feeding practices for preterm infants have been previously surveyed,16–18 but practices between countries have not been compared. The objective of this survey was to evaluate and compare the clinical practices of enteral feeding in very preterm infants among neonatal units in four different geographical regions.…”

Section: Introductionmentioning

confidence: 99%

Enteral feeding practices in very preterm infants: an international survey

Klingenberg

Embleton

Jacobs

et al. 2011

Arch Dis Child Fetal Neonatal Ed

185

136

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“…Logistic regression adjusting for gestation at birth and age at starting feed showed a significant interaction between PDA and sepsis (p = 0.030). Compared with neonates with no or insignificant PDA and no sepsis, all other neonates were more likely to experience a prolonged interval between starting feed and full enteral feed (sepsis alone: odds ratio (OR) 10 …”

Section: Resultsmentioning

confidence: 99%