2021
DOI: 10.1159/000516640
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Enteral Feeding Strategies in Preterm Neonates ≤32 weeks Gestational Age: A Systematic Review and Network Meta-Analysis

Abstract: <b><i>Introduction:</i></b> Critical aspects of time of feed initiation, advancement, and volume of feed increment in preterm neonates remain largely unanswered. <b><i>Methods:</i></b> Medline , Embase, CENTRAL and CINAHL were searched from inception until 25th September 2020. Network meta-analysis with the Bayesian approach was used. Randomized controlled trials (RCTs) evaluating preterm neonates ≤32 weeks were included. Feeding regimens were divided based on t… Show more

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Cited by 7 publications
(4 citation statements)
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“…The average starting time of enteral feeding of the EUGR group in this study was later than that in the non-EUGR group (36.00 h vs. 21.75 h). A delay in enteral feeding might cause gastrointestinal mucosa atrophy and delayed functional maturity and also increase the incidence of FI ( P = 0.031) and NEC [ 40 , 41 ]. The incidence of LOS among infants in the EUGR group was higher than that among infants in the non-EUGR group ( P = 0.022), which led to longer administration of antibiotics ( P = 0.011), greater extent of intestinal microecology disorder and a higher incidence of NEC among infants in the EUGR group [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…The average starting time of enteral feeding of the EUGR group in this study was later than that in the non-EUGR group (36.00 h vs. 21.75 h). A delay in enteral feeding might cause gastrointestinal mucosa atrophy and delayed functional maturity and also increase the incidence of FI ( P = 0.031) and NEC [ 40 , 41 ]. The incidence of LOS among infants in the EUGR group was higher than that among infants in the non-EUGR group ( P = 0.022), which led to longer administration of antibiotics ( P = 0.011), greater extent of intestinal microecology disorder and a higher incidence of NEC among infants in the EUGR group [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Early attainment and maintenance of adequate EN can promote growth and weight recovery in preterm infants, and it can reduce the short-term and long-term complications ( 8 , 26 ). A long time required to reach total EN is an independent risk factor for “true EUGR” in VPI.…”
Section: Discussionmentioning
confidence: 99%
“…(7) Growth velocity after regaining BW was calculated as follows: GV = [1000 × ln (Wn/W1)]/(Dn-D1) (13), Wn, discharged weight; W1, BW; Dn, length of hospital stay; D1, days to regain BW. (8) The diagnoses of RDS, EOS, LOS, NEC ≥ stage 2, IVH grade III-IV, PVL, FI, MBDP, PNAC, and anemia were established by referring to Practical Neonatology (5th edition) (14).…”
Section: Data Collectionmentioning
confidence: 99%
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