Enteral long-chain polyunsaturated fatty acids and necrotizing enterocolitis: A systematic review and meta-analysis

Alshaikh, Belal; Loredo, Adriana Reyes; Yusuf, Kamran; Maarouf, Ahmed A.; Fenton, Tanis R.; Momin, Sarfaraz

doi:10.1016/j.ajcnut.2023.01.007

Cited by 6 publications

(3 citation statements)

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“…Although studies indicated the potential positive effects of LCPUFA supplementation on neurodevelopment and vision, recent large, randomized trials revealed concerns about the possible increase in risk [ 59 ]. A recent meta-analysis concluded that supplementation with DHA alone increased necrotizing enterocolitis (NEC), but when ARA and DHA supplementation were combined, it increased NEC incidence [ 59 ]. LCPUFA supplementation modulated the inflammatory process in the pathophysiology of NEC [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis concluded that supplementation with DHA alone increased necrotizing enterocolitis (NEC), but when ARA and DHA supplementation were combined, it increased NEC incidence [ 59 ]. LCPUFA supplementation modulated the inflammatory process in the pathophysiology of NEC [ 59 ]. Also, results indicate that enteral DHA supplementation reduced NEC incidence among preterm infants due to their immunoregulatory effect [ 59 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

“…LCPUFA supplementation modulated the inflammatory process in the pathophysiology of NEC [ 59 ]. Also, results indicate that enteral DHA supplementation reduced NEC incidence among preterm infants due to their immunoregulatory effect [ 59 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Holder Pasteurization, Mode of Delivery, and Infant’s Gender on Fatty Acid Composition of Donor Breast Milk

Vass,

Zhang,

Simon Sarkadi

et al. 2024

Nutrients

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Breast milk (BM) plays a crucial role in providing essential fatty acids (FA) and energy for the growing infant. When the mother’s own BM is not available, nutritional recommendations suggest donor milk (DM) in clinical and home practices. BM was collected from a variety of donor mothers in different lactation stages. Holder pasteurization (HoP) eliminates potential contaminants to ensure safety. FA content of BM samples from the Breast Milk Collection Center of Pécs, Hungary, were analyzed before and after HoP. HoP decreases the level of C6:0, C8:0, C14:1n-5c, C18:1n-9c, C18:3n-6c, C18:3n-3c, and C20:4n-6c in BM, while C14:0, C16:0, C18:1n-9t, C22:0, C22:1n-9c, C24:0, C24:1n-9c, and C22:6n-3c were found in elevated concentration after HoP. We did not detect time-dependent concentration changes in FAs in the first year of lactation. BM produced for girl infants contains higher C20:2n-6c levels. In the BM of mothers who delivered via cesarean section, C12:0, C15:0, C16:0, C17:0, C18:0, C18:1n-9t, C22:1n-9c levels were higher, while C18:2n-6c, C22:0, C24:0, and C22:6n-3c concentrations were lower compared to mothers who gave birth spontaneously. FAs in BM are constant during the first year of lactation. Although HoP modifies the concentration of different FAs, pasteurized DM provides essential FAs to the developing infant. Current data providing information about the FA profile of BM gives origination to supplementation guidelines.

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Section: Discussionmentioning

confidence: 99%