Enteral nutrition formulations for acute pancreatitis

Poropat, Goran; Giljača, Vanja; Hauser, Goran; Štimac, Davor

doi:10.1002/14651858.cd010605.pub2

Cited by 62 publications

(37 citation statements)

References 66 publications

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“…The potential value of using probiotics for patients with severe acute pancreatitis has been evaluated in randomized controlled trials and summarized in a Cochrane review and a meta-analysis. 40, 41 Overall, probiotics have been shown to have no significant beneficial nor adverse effects in patients with severe acute pancreatitis. One caveat is that these trials had significant heterogeneity with respect to patient characteristics and probiotic regimens.…”

Section: Introductionmentioning

confidence: 99%

The Gut Microbiome in Pancreatic Disease

Akshintala¹,

Talukdar

Singh³

et al. 2019

Clinical Gastroenterology and Hepatology

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The gut microbiome is increasingly recognized for its role in human health and disease. Initial evidence indicates that gut microbial dysbiosis is associated with several pancreatic diseases. Although it is not known if these associations are causative, gut dysbiosis is hypothesized to mediate chronic pro-inflammatory changes in the pancreas. Further mechanistic and epidemiological studies of the microbiome are needed. Ultimately, targeted modulation of the microbiota could have therapeutic value.

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Section: Introductionmentioning

confidence: 99%

The Gut Microbiome in Pancreatic Disease

Akshintala¹,

Talukdar

Singh³

et al. 2019

Clinical Gastroenterology and Hepatology

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“…Furthermore, it reduced intestinal motility, increased mucous secretion and improved the survival rate of the treated animals (Chen et al , ). In addition, there are multiple other reports including clinical studies, which strongly indicate that rhubarb can be a potential phytoremedy for the treatment of pancreatitis (Donghai, ; Chen and Ran, ; Zheng et al , ; Poropat et al , ). Thus, use of rhubarb‐derived products including different extracts may be useful to treat AP clinically and may aid in management of the diseases.…”

Section: Herbal Remedies Used For Treating Pancreatitismentioning

confidence: 99%

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Timing of EN is discussed separately. Nasogastric tube feeding does not reduce patient quality of life compared to nil by mouth [46] and feeding by nasogastric or nasojejunal routes have comparable effectiveness and safety [47e49], as do polymeric and the more expensive (semi)elemental formulations [50,51].…”

Section: Response To Treatmentmentioning

confidence: 99%

“…with glutamine) is helpful and fiber enrichment is not discussed in any of the guidelines [17,18,30]. Similarly, conclusions of the 2015 Cochrane Database Systematic Review [51] are that further research is required to determine if immunomodulatory agents improve clinically meaningful outcomes (a possibility supported by a meta-analysis of 10 heterogeneous studies [56]) and that "Evidence remains insufficient to support the use of a specific EN formulation". PN should be avoided unless the alternative is no feeding, the latter which carries a higher risk of mortality but not infection compared to PN [51,57].…”

Section: Response To Treatmentmentioning

confidence: 99%

Clinical update on fluid therapy and nutritional support in acute pancreatitis

DiMagno

2015

Pancreatology

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Enteral nutrition formulations for acute pancreatitis

Cited by 62 publications

References 66 publications

The Gut Microbiome in Pancreatic Disease

The Gut Microbiome in Pancreatic Disease

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

Clinical update on fluid therapy and nutritional support in acute pancreatitis

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