Enteral nutrition supplemented with l-glutamine in patients with systemic inflammatory response syndrome due to pulmonary infection

Cavalcante, Ana Augusta Monteiro; Campelo, Marcio Wilker Soares; Vasconcelos, Marcelo Pinho Pessoa de; Ferreira, Camila Marques; Guimarães, Sérgio Botelho; Garcia, José Huygens Parente; Vasconcelos, Paulo Roberto Leitão de

doi:10.1016/j.nut.2011.07.011

Cited by 25 publications

(11 citation statements)

References 19 publications

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“…Mean duration of the interventions were 19 days. Three studies were performed in women (Dock-Nascimento et al, 2012a, 2012bLaviano et al, 2014), five on men (Caris et al, 2014;Krzywkowski et al, 2001;Letellier et al, 2013;Du et al, 2018;Torres-Santiago et al, 2017) and nine trials involved both sexes (Mansour et al, 2015;Torres-Santiago et al, 2017;Cavalcante et al, 2012;Cui et al, 2014;Darmaun et al, 2004;Duska et al, 2008;Lomivorotov et al, 2013;Rotovnik Kozjek et al, 2011;Rotovnik Kozjek et al, 2017;Singh et al, 2015). The mean FBS, insulin level and HOMA-IR at baseline were 92.61 mg/dl, 11.93 units and 1.81 units, respectively, in the intervention group, and 94.08 mg/dl, 14.95 units and 1.87 units, respectively, in the placebo group.…”

Section: Study Characteristicsmentioning

confidence: 99%

Does glutamine supplementation have favorable effects on glucose control and insulin sensitivity?

Kord‐Varkaneh

Salehi‐Sahlabadi

Mousavi

et al. 2019

NFS

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Purpose The authors performed a systematic review and meta-analysis of all published randomized controlled trials with the aim to determine and quantify the anti-hyperglycemic effects of glutamine (Gln) in acute and chronic clinical settings. Design/methodology/approach The authors conducted a comprehensive search of all randomized clinical trials performed up to December 2018, to identify those investigating the impact of Gln supplementation on fasting blood sugar (FBS), insulin levels and homeostatic model assessment-insulin resistance (HOMA-IR) via ISI Web of Science, Cochrane library PubMed and SCOPUS databases. A meta-analysis of eligible studies was conducted using random effects model to estimate the pooled effect size. Fractional polynomial modeling was used to explore the dose–response relationships between Gln supplementation and diabetic indices. Findings The results of the present meta-analysis suggest that of Gln supplementation had a significant effect on FBS (weighted mean difference (WMD): –2.868 mg/dl, 95 per cent CI: –5.467, –0.269, p = 0.031). However, the authors failed to observe that Gln supplementation affected insulin levels (WMD: 1.06 units, 95 per cent CI: –1.13, 3.26, p = 0.34) and HOMA-IR (WMD: 0.001 units, 95 per cent CI: –2.031, 2.029, p = 0.999). Subgroup analyses showed that the highest decrease in FBS levels was observed when the duration of intervention was less than two weeks (WMD: –4.064 mg/dl, 95 per cent CI: –7.428, –0.700, p = 0.01) and when Gln was applied via infusion (WMD: –5.334 mg/dl, 95 per cent CI: –10.48, 0.17, p = 0.04). Originality/value The results from this meta-analysis show that Gln supplementation did not have a significant effect on insulin levels and HOMA-IR. However, it did significantly reduce the levels of FBS, obtaining a higher effect when the duration of the intervention period was less than two weeks.

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Section: Study Characteristicsmentioning

confidence: 99%

Does glutamine supplementation have favorable effects on glucose control and insulin sensitivity?

Kord‐Varkaneh

Salehi‐Sahlabadi

Mousavi

et al. 2019

NFS

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“…In a small, controlled crossover study [16], 30 enterally fed ICU patients received two successive 2-day enteral supplementations with either GLN 30 g/day or isonitrogenous caseinate. These ICU patients were hemodynamically stable, but exhibited a systemic inflammatory response syndrome because of pulmonary infection.…”

Section: Key Pointsmentioning

confidence: 99%

Glutamine in the intensive care unit

Cynober¹,

Bandt²

2013

Current Opinion in Clinical Nutrition and Metabolic Care

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“…Its characteristics are not essential, and there are almost no existing pathologies with glutamine disturbances. Specifically, only three cases have been reported globally 2,3 . Its metabolism is linked to the ammonia cycle 2,3 , which is relevant and poses risks to human health.…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, only three cases have been reported globally 2,3 . Its metabolism is linked to the ammonia cycle 2,3 , which is relevant and poses risks to human health. Glutamine use was evaluated in a clinical trial with children in severe disease states.…”

Section: Introductionmentioning

confidence: 99%

Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats

Silva

Segundo

Semenoff

et al. 2018

Rev. odontol. UNESP

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ResumoIntrodução: Com a suplementação de glutamina há um melhor desempenho no sistema de defesa do corpo. Objetivo: O objetivo deste estudo foi analisar o efeito da suplementação de glutamina na doença periodontal induzida por ligatura em ratos. Material e método: Foram selecionados 48 ratos machos da linhagem Wistar divididos em 4 grupos (N = 12): grupo controle (GC) incluindo animais saudaveis recebendo solução salina diariamente via gavagem; grupo glutamina (GG) incluindo animais saudaveis que receberam suplementação oral de glutamina por gavagem a uma dose de 1,5 g/kg/dia; grupo periodontite (GP) incluindo animais com doença periodontal induzida na maxila em ambos os lados recebendo solução salina diária via gavagem; grupo experimental (GE) incluindo animais com doença periodontal induzida na maxila nos dois lados recebendo glutamina diária via gavagem na dose de 1,5 g/kg/dia. No 30º dia, todos os animais foram eutanasiados por excesso de anestésico. Descritores: Suplementos nutricionais; doenças periodontais; produtos com ação antimicrobiana. AbstractIntroduction: With glutamine supplementation there is better performance in the body's defense system. Objective: The aim of this study was to analyze the effect of glutamine supplementation on ligand-induced periodontal disease in rats. Material and method: 48 selected male Wistar rats were divided into 4 groups (N = 12): control group (CG) including healthy animals receiving daily saline solution via gavage; glutamine group (GG) including healthy animals receiving oral glutamine supplementation by gavage at a dose of 1.5 g / kg / day; periodontitis group (PG) including animals with induced periodontal disease on both upper sides receiving daily saline solution via gavage; experimental group (EG) including animals with induced periodontal disease on both upper sides receiving daily glutamine via gavage at a dose of 1.5 g / kg / day. On the 30th day, all animals were euthanized by excess anesthetic.

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Enteral nutrition supplemented with l-glutamine in patients with systemic inflammatory response syndrome due to pulmonary infection

Cited by 25 publications

References 19 publications

Does glutamine supplementation have favorable effects on glucose control and insulin sensitivity?

Does glutamine supplementation have favorable effects on glucose control and insulin sensitivity?

Glutamine in the intensive care unit

Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats

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