Enteral oxygen therapy: new approaches to rehabilitation for chronic gastroduodenal pathology in children

Abstract

Purpose. Studying the effect of enteral oxygen therapy (EOT), in the process of rehabilitation, on the regenerative process of the mucous membrane of the gastrointestinal tract in children with chronic gastroduodenal pathology (CGDP). Methods. The clinical observation was based on a randomized study. We examined 286 children with CGDP. The research methods fibrogastroduodenoscopy (FGDS), and tests for Helicobacter pylori infection. Results. Based on the results of the FGDS, we developed a scoring scale for the regeneration process (SSRP) without morphological biopsy. According to the results of the SSRP, in patients with inflammatory processes, after a course of standard inpatient treatment, there was a 3rd degree of regeneration, with ulcerative lesions - 4th degree. After a single rehabilitation course, using EOT, a transition to 1-degree regeneration was noted (6.6±0.77 points), without the use of EOT for 2-degree (10.9±1.23 points). The data indicated a more than 63% increase in reparative-regenerative processes when using EOT. Against this background, there was up to a 2.5-fold decrease in Helicobacter pylori carriage. Conclusions. The use of EOT helps to accelerate regenerative mechanisms of the gastric mucosa by up to 63%, and the implementation of a comprehensive rehabilitation program using EOT contributes to a significant decrease in Helicobacter pylori carriage.