Enteric glial cells contribute to chronic stress-induced alterations in the intestinal microbiota and barrier in rats

Lu, Tong; Huang, Chenxu; Weng, Rongxin; Wang, Zepeng; Sun, Haiji; Ma, Xiaoli

doi:10.1016/j.heliyon.2024.e24899

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e24899

|View full text |Cite

Enteric glial cells contribute to chronic stress-induced alterations in the intestinal microbiota and barrier in rats

Tong Lu,

Chenxu Huang,

Rongxin Weng

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Astrocyte Marker GFAP in Gliocytes of Peripheral Nervous System

Petrova,

Kolos

2024

J Evol Biochem Phys

View full text Add to dashboard Cite

Astrocyte Marker GFAP in Gliocytes of Peripheral Nervous System

Petrova,

Kolos

2024

J Evol Biochem Phys

View full text Add to dashboard Cite

Astrocyte marker GFAP in gliocytes of the peripheral nervous system

Petrova,

Kolos

2024

Rossijskij fiziologičeskij žurnal im. I.M. Sečenova

View full text Add to dashboard Cite

The study of peripheral nervous system glial cells is an actual problem of modern neurobiology. The purpose of this work was to summarize our own and published data on the distribution of glial fibrillary acidic protein (GFAP) in peripheral nervous system (PNS) glial cells. The features of GFAP expression in glial cells of the enteric nervous system, dorsal root ganglion and peripheral nerve were examined. A comparative study of different populations of PNS gliocytes led to the conclusion that the intermediate filament protein GFAP is distributed differently in them. Analysis of the literature showed that despite the fact that this protein is widely used as a molecular marker of glial activation, there is still no understanding of the exact mechanisms of GFAP participation in the glial reactive response. The described features of GFAP+gliocytes from different parts of the PNS demonstrate the functional polymorphism of this protein. Its ability to be expressed in peripheral nervous system gliocytes in response to injury requires further research.

show abstract

Do enteric glial cells play a role in the pathophysiology of major depression?

Rajkumar

2024

Explor Neurosci

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a common mental disorder associated with significant suffering and disability. Recent evidence has highlighted the role of the gut-brain axis in the pathogenesis of MDD. Enteric glial cells are a structurally and functionally diverse population that plays a key role in regulating enteric nervous function and maintaining intestinal mucosal integrity. These cells may be implicated in the origin of several digestive and extra-digestive disorders, known as enteric neuro-gliopathies (ENG). This paper reviews the evidence that MDD may also belong to the category of ENG. Animal models suggest that environmental adversity can lead to enteric glial dysfunction and depressive-like behaviors. Conditions that are highly comorbid with MDD, both intestinal and extra-intestinal, have been linked to enteric glial alterations. Peripheral blood markers linked to glial integrity and function are altered in patients with MDD, and certain treatments for MDD may have beneficial effects on enteric glial functioning. Though much of this evidence is indirect and provisional, it suggests that MDD may belong to the group of ENG. Further investigation of enteric glial functioning in MDD may yield valuable insights into the pathophysiology and treatment of this disorder.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Enteric glial cells contribute to chronic stress-induced alterations in the intestinal microbiota and barrier in rats

Cited by 3 publications

References 61 publications

Astrocyte Marker GFAP in Gliocytes of Peripheral Nervous System

Astrocyte Marker GFAP in Gliocytes of Peripheral Nervous System

Astrocyte marker GFAP in gliocytes of the peripheral nervous system

Do enteric glial cells play a role in the pathophysiology of major depression?

Contact Info

Product

Resources

About