Enteritis due to enteropathogenic escherichia coli

Neter, Erwin

doi:10.1007/bf02236098

Cited by 27 publications

(9 citation statements)

References 4 publications

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“…coined the term ‘enteropathogenic E. coli ’ (EPEC) as a descriptor for strains of E. coli that are primary intestinal pathogens, as opposed to strains whose normal habitat is the intestine and that cause opportunistic infections when introduced into extraintestinal tissues. Several years later, Neter 8 cited some of the evidence in support of the pathogenicity of EPEC strains as follows: (i) EPEC are more frequently isolated from children with diarrhea than from healthy control subjects; (ii) EPEC are associated with institutional outbreaks; (iii) some strains cause diarrhea in volunteers; (iv) patients and volunteers infected with EPEC develop a specific serological response to the infecting bacteria; and (v) treatment with antibiotics to which the bacteria are susceptible shortens the course of the illness and can interrupt outbreaks. In the ensuing years, infections with EPEC in industrialized countries became less frequent and interest in these bacteria waned.…”

Section: Historical Background: Recognition Of Escherichia Coli As a mentioning

confidence: 99%

Escherichia coli as a cause of diarrhea

Robins-Browne

Hartland

2002

J of Gastro and Hepatol

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Escherichia coli is the best-known member of the normal microbiota of the human intestine and a versatile gastrointestinal pathogen. The varieties of E. coli that cause diarrhea are classified into named pathotypes, including enterotoxigenic, enteroinvasive, enteropathogenic and enterohemorrhagic E. coli. Individual strains of each pathotype possess a distinct set of virulence-associated characteristics that determine the clinical, pathological and epidemiological features of the diseases they cause. In the present brief review, we summarize the key distinguishing features of the major pathotypes of diarrheagenic E. coli. Knowledge of the pathogenic mechanisms of these bacteria has led to the development of rational interventions for the treatment and prevention of E. coli-induced diarrhea. In addition, investigations into E. coli virulence are providing useful insights into the origins and evolution of bacterial pathogens more generally.

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Section: Historical Background: Recognition Of Escherichia Coli As a mentioning

confidence: 99%

Escherichia coli as a cause of diarrhea

Robins-Browne

Hartland

2002

J of Gastro and Hepatol

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“…The term enteropathogenic Escherichia coli (EPEC) was first used by Neter (7) to refer to the serotypes of E. coli associated with diarrhea in humans. Now this term is used to designate strains of E. coli that cause diarrhea but do not produce heat-labile or heat-stable enterotoxins and are not enteroinvasive as indicated by the Sereny test (5).…”

mentioning

confidence: 99%

Pathogenicity of attaching effacing enteropathogenic Escherichia coli isolated from diarrheic suckling and weanling rabbits for newborn rabbits

Peeters¹,

Charlier²,

Halen³

1984

Infect Immun

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The pathogenicity of six strains of Escherichia coli originating from different commercial rabbitries was tested in neonatal rabbits. Two strains isolated from healthy weaned rabbits (O7:H6 and O9:H?) did not induce any clinical sign or lesion. Two strains (O109:H2) isolated from diarrheic suckling rabbits caused yellow diarrhea 36 to 60 h after inoculation and high mortality between 60 and 72 h after infection. At 12 h after infection, light and electron microscopy showed attachment to epithelial cells and effacement of microvilli from proximal small intestine to colon. Bacteria were often present in the apical cytoplasm of epithelial cells. The two strains isolated from diarrheic weanling rabbits (O109:H2 and O15:H-) did not induce any clinical sign. Attachment to epithelial cells and effacement of microvilli was observed 48 h after inoculation in distal small intestine, cecum, and colon. These data are further evidence for the existence of two groups of attaching effacing enteropathogenic E. coli in rabbits, showing different preferences for age group and intestinal compartment.

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“…IT has been recognised for many years that breast-fed babies are relatively resistant to gastro-enteritis (Alexander, 1948 ;Ross and Dawes, 1954;Hinton and MacGregor, 1958). Various explanations have been put forward to account for this resistance, including passive transfer of antibodies to Escherichia coli in colostrum (Sussman, 1961 ;Michael, Ringenback and Hottenstein, 1971), contamination of artificial feeds during preparation (Neter, 1959), and the nature of the intestinal environment (Ross and Dawes, 1954). The continuing incidence of enteropathogenic E. coli infections in young infants, together with the decline in the popularity of breast feeding, has led us to re-examine this problem.…”

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confidence: 99%

Bifidobacteria in the intestinal tract of infants: an in-vivo study

Bullen

Tearle

Willis

1976

Journal of Medical Microbiology

156

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PLATE XXIV IT is well known that the nature of the milk fed to newborn infants greatly influences the physico-chemical and microbiological properties of their faeces. The most prominent features of the faeces of breast-fed infants in comparison with those of bottle-fed infants are a preponderance of bifidobacteria, a low pH and a virtual absence of putrefactive organisms, and it has been customary to regard this triad as sequentially related. The results of studies in vivo indicate that although pH does influence the nature of the bacterial flora, of much greater importance in this respect is the presence of an acetic acid and acetate buffer (Willis et al., 1973; Bullen, Tearle and Willis, 1976). The aim of the present study was to determine the principal source of acetic acid in infant faeces and the effect of both acetic acid and of an acetic acid and acetate buffer on the growth of certain common faecal bacteria and enteric pathogens. biotype El Tor, one laboratory strain. The laboratory strains were isolated from the faeces of infants except for the strains of C. perfringens, Salm. typhimurium, Shig. sonnei and V. cholerae El Tor, which were isolated from older patients. Acetate buflers. A series of nine acetate buffers in the range of pH 3.8-6.2 were prepared as described by Cruickshank et al. (1975). VLG medium (Beerens, et al., 1963). This fluid medium, which contains 1 % glucose, was used in 20-ml aliquots in Universal containers for the production of acetic acid by bacterial cultures. Modified reinforced clostridial medium (RCM). This was the Oxoid CM 149 formulation (Oxoid Manual, 1973) from which soluble starch, sodium acetate, and agar were omitted. It formed the nutrient basis of acetate-bufFered RCM and unbuffered RCM. Acetate-buflered RCM. Modified Reinforced Clostridial Media buffered at nine different pH values over the range of 3.8-6.2 were prepared by adding the basic ingredients to aliquots

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Enteritis due to enteropathogenic escherichia coli

Cited by 27 publications

References 4 publications

Escherichia coli as a cause of diarrhea

Escherichia coli as a cause of diarrhea

Pathogenicity of attaching effacing enteropathogenic Escherichia coli isolated from diarrheic suckling and weanling rabbits for newborn rabbits

Bifidobacteria in the intestinal tract of infants: an in-vivo study

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