Enterobacter aerogenes Hormaeche and Edwards 1960 (Approved Lists 1980) and Klebsiella mobilis Bascomb et al. 1971 (Approved Lists 1980) share the same nomenclatural type (ATCC 13048) on the Approved Lists and are homotypic synonyms, with consequences for the name Klebsiella mobilis Bascomb et al. 1971 (Approved Lists 1980)

Tindall, Brian J.; Sutton, Granger

doi:10.1099/ijsem.0.001572

Cited by 105 publications

(53 citation statements)

References 13 publications

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“…It is apparent from the tree that E. aerogenes is more closely related to K. pneumoniae than to the E. cloacae complex (23). This is consistent with previous findings and proposals to rename the species: K. mobilis (37–39), K. aeromobilis (23), and very recently K. aerogenes (40). …”

Section: Resultssupporting

confidence: 93%

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Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms

Chavda

Chen

Fouts

et al. 2016

mBio

167

159

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Knowledge regarding the genomic structure of Enterobacter spp., the second most prevalent carbapenemase-producing Enterobacteriaceae, remains limited. Here we sequenced 97 clinical Enterobacter species isolates that were both carbapenem susceptible and resistant from various geographic regions to decipher the molecular origins of carbapenem resistance and to understand the changing phylogeny of these emerging and drug-resistant pathogens. Of the carbapenem-resistant isolates, 30 possessed blaKPC-2, 40 had blaKPC-3, 2 had blaKPC-4, and 2 had blaNDM-1. Twenty-three isolates were carbapenem susceptible. Six genomes were sequenced to completion, and their sizes ranged from 4.6 to 5.1 Mbp. Phylogenomic analysis placed 96 of these genomes, 351 additional Enterobacter genomes downloaded from NCBI GenBank, and six newly sequenced type strains into 19 phylogenomic groups—18 groups (A to R) in the Enterobacter cloacae complex and Enterobacter aerogenes. Diverse mechanisms underlying the molecular evolutionary trajectory of these drug-resistant Enterobacter spp. were revealed, including the acquisition of an antibiotic resistance plasmid, followed by clonal spread, horizontal transfer of blaKPC-harboring plasmids between different phylogenomic groups, and repeated transposition of the blaKPC gene among different plasmid backbones. Group A, which comprises multilocus sequence type 171 (ST171), was the most commonly identified (23% of isolates). Genomic analysis showed that ST171 isolates evolved from a common ancestor and formed two different major clusters; each acquiring unique blaKPC-harboring plasmids, followed by clonal expansion. The data presented here represent the first comprehensive study of phylogenomic interrogation and the relationship between antibiotic resistance and plasmid discrimination among carbapenem-resistant Enterobacter spp., demonstrating the genetic diversity and complexity of the molecular mechanisms driving antibiotic resistance in this genus.

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Section: Resultssupporting

confidence: 93%

“…Groups containing type strains were given specific species names; otherwise, just “ cloacae complex” was used with the strain name. The distinct phylogenomic grouping of E. aerogenes on the basis of whole-genome sequencing clearly supports the previously proposed argument to rename this species K. aerogenes (40). …”

Section: Discussionsupporting

confidence: 85%

Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms

Chavda

Chen

Fouts

et al. 2016

mBio

167

159

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“…Among the PGPR were the actinomycetes Frankia sp DSM 45818 (CPN9), S treptomyces galilaeus (CPN7), and S. griseoaurantiacus (CPN8), which were isolated from nodules. Several isolates were identified as pathogens or nosocomial pathogens including Klebsiella aerogenes (CPN11 and CPN20) (formerly Enterobacter ) (Tindal et al 2017), Aeronomas veronii (CPN19) (Janda and Abbott 2010), Pseudomonas monteilii (CPN44) (Elomari et al 1997), and Enterobacter cloacae (CPN48) (Sanders and Sanders 1997) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Impact of soil salinity on the cowpea nodule-microbiome and the isolation of halotolerant PGPR strains to promote plant growth under salinity stress

Mukhtar

Hirsch²,

Khan

et al. 2019

Preprint

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Four soil samples (SS-1-SS-4) isolated from semi-arid soils in Punjab, Pakistan were used as inocula for cowpea (Vigna unguiculata L.) grown under salinity stress to analyze the composition of bacteria in the rhizosphere and within nodules through cultivation-dependent and cultivationindependent methods. Two cowpea varieties, 603 and the salt-tolerant CB 46, were each inoculated with four different native soil samples, and data showed that plants inoculated with soil samples SS-2 and SS-4 grew better than plants inoculated with soil samples SS-1 and SS-3. Bacteria were isolated from both soils and nodules, and 34 of the 51 original isolates tested positive for PGPR traits in plate assays with many exhibiting multiple plant growth-promoting properties. A number of isolates were positive for all PGPR traits tested. For the microbiome studies, environmental DNA (eDNA) was isolated from SS-1 and SS-4, which represented the extremes of the Pakistan soils to which the plants responded, and by 16S rRNA gene sequencing analysis were found to consist mainly of Actinobacteria, Firmicutes, and Proteobacteria. However, sequencing analysis of eDNA isolated from cowpea nodules established by the trap plants grown in the four Pakistan soils indicated that the nodule microbiome consisted almost exclusively of Proteobacterial sequences, particularly Bradyrhizobium. Yet, many other bacteria including Rhizobium, Mesorhizobium, Pseudomonas, as well as Paenibacillus, Bacillus as well as non-proteobacterial genera were isolated from the nodules of soil-inoculated cowpea plants. This discrepancy between the bacteria isolated from cowpea nodules (Proteobacteria and non-Proteobacteria) versus those detected in the nodule microbiome (Proteobacteria) needs further study.

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“…The glycine in position 53 of BasR has previously been reported to be altered in colistin-resistant Enterobacteriaceae (53, 54) including in E. coli (55). The G53S change specifically, as in isolate H2192, has been experimentally proven to contribute to colistin resistance in Klebsiella (previously Enterobacter ) aerogenes (56, 57) and Salmonella enterica subsp. enterica serovar Typhimurium (58) and we extend those findings to E. coli here.…”

Section: Discussionmentioning

confidence: 99%

Non-clonal emergence of colistin resistance associated with mutations in the BasRS two-component system in Escherichia coli bloodstream isolates

Janssen

Bartholomew

Marciszewska

et al. 2019

Preprint

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1 8 1 9Infections by multidrug-resistant Gram-negative bacteria are increasingly common, 2 0 prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative 2 1 bacteria by interacting with the anionic lipid A moieties of lipopolysaccharides, leading to 2 2 membrane destabilization and cell death. Here, we aimed to uncover the mechanisms of colistin 2 3 resistance in nine colistin-resistant Escherichia coli strains and one E. albertii strain. These were 2 4 the only colistin-resistant strains out of 1140 bloodstream Escherichia isolates collected in a 2 5tertiary hospital over a ten-year period (2006 -2015). Core genome phylogenetic analysis 2 6 showed that each patient was colonised by a unique strain, suggesting that colistin resistance was 2 7 acquired independently in each strain. All colistin-resistant strains had lipid A that was modified 2 8 with phosphoethanolamine. In addition, two E. coli strains had hepta-acylated lipid A species, 2 9containing an additional palmitate compared to the canonical hexa-acylated E. coli lipid A. One 3 0 E. coli strain carried the mobile colistin resistance (mcr) gene mcr-1.1 on an IncX4-type plasmid. 3 1

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Cited by 105 publications

References 13 publications

Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms

Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms

Impact of soil salinity on the cowpea nodule-microbiome and the isolation of halotolerant PGPR strains to promote plant growth under salinity stress

Non-clonal emergence of colistin resistance associated with mutations in the BasRS two-component system in Escherichia coli bloodstream isolates

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