Enterococcal Infections in Adults

Reyes, Katherine; Zervos, Marcus J.; John, J.W.Banerjee

doi:10.1007/978-3-319-47266-9_3

Cited by 4 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antimicrobials consumption constitutes an important risk factor for colonization with multi-drug resistant enterococci because of the suppression of the competitive indigenous microbiota in the gastrointestinal tract. The increased number of gut enterococci, due to the decrease of competitive gut indigenous flora, frequently precedes bloodstream infections (Ubeda et al, 2010; Reyes et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Impact on Public Health of the Spread of High-Level Resistance to Gentamicin and Vancomycin in Enterococci

2018

View full text Add to dashboard Cite

Antibiotic resistance has turned into a global public health issue. Enterococci are intrinsically resistant to many antimicrobials groups. These bacteria colonize dairy and meat products and integrate the autochthonous microbiota of mammal’s gastrointestinal tract. Over the last decades, detection of vanA genotype in Enterococcus faecium from animals and from food of animal origin has been reported. Vancomycin-resistant E. faecium has become a prevalent nosocomial pathogen. Hospitalized patients are frequently treated with broad-spectrum antimicrobials and this leads to an increase in the presence of VanA or VanB vancomycin-resistant enterococci in patients’ gastrointestinal tract and the risk of invasive infections. In humans, E. faecium is the main reservoir of VanA and VanB phenotypes. Acquisition of high-level aminoglycoside resistance is a significant therapeutic problem for patients with severe infections because it negates the synergistic effect between aminoglycosides and a cell-wall-active agent. The aac(6′)-Ie-aph (2″)-Ia gene is widely spread in E. faecalis and has been detected in strains of human origin and in the food of animal origin. Enzyme AAC(6′)-Ie-APH(2″)-Ia confers resistance to available aminoglycosides, except to streptomycin. Due to the fast dissemination of this genetic determinant, the impact of its horizontal transferability among enterococcal species from different origin has been considered. The extensive use of antibiotics in food-producing animals contributes to an increase in drug-resistant animal bacteria that can be transmitted to humans. Innovation is needed for the development of new antibacterial drugs and for the design of combination therapies with conventional antibiotics. Nowadays, semi-purified bacteriocins and probiotics are becoming an attractive alternative to the antibiotic in animal production. Therefore, a better understanding of a complex and relevant issue for Public Health such as high-level vancomycin and gentamicin resistance in enterococci and their impact is needed. Hence, it is necessary to consider the spread of vanA E. faecium and high-level gentamicin resistant E. faecalis strains of different origin in the environment, and also highlight the potential horizontal transferability of these resistance determinants to other bacteria.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact on Public Health of the Spread of High-Level Resistance to Gentamicin and Vancomycin in Enterococci

2018

View full text Add to dashboard Cite

show abstract

“…Antimicrobial consumption through food or any other sources continuously leads to the suppression of intestinal microbiota that guards against pathogenic bacteria. Moreover, their presence in the bloodstream leads to the malfunctioning of various organs (2,3). Extensive use of antimicrobials in animals may lead to the production of .…”

Section: Introductionmentioning

confidence: 99%

Vancomycin drug resistance, an emerging threat to animal and public health

Aqib

Alsayeqh

2022

Front. Vet. Sci.

View full text Add to dashboard Cite

The need to supply quality food for the growing human population has led to the revolutionization of food production and processing in recent years. Meanwhile, food production sources are at risk of microbial attack, while the use of antibiotics to counter them is posing another threat to food safety and security. Vancomycin was used as the first line of defense against multiple drug-resistant bacteria salient of which is methicillin-resistant S. aureus. The emergence of the vancomycin resistance gene in bacteria impairs the efficacy of antibiotics on the one hand while its harmful residues impart food safety concerns on the other. Currently, a novel set of resistance genes “Van cluster” is circulating in a wider range of bacteria. Considerable economic losses in terms of low production and food safety are associated with this emerging resistance. The current review focuses on the emergence of vancomycin resistance and its impact on food safety. The review proposes the need for further research on the probable routes, mechanisms, and implications of vancomycin resistance from animals to humans and vice versa.

show abstract

Investigation of Virulence Factors Using Phenotypic and Genotypic Methods in High-Level Aminoglycoside Resistant Enterococci Isolated From Cheese

Tuncer

Adifon

2019

Gıda

View full text Add to dashboard Cite

Bu çalışmanın amacı daha önce peynir örneklerinden izole edilen yüksek-seviyede aminoglikozid dirençli (YSAD) 54 enterokok izolatında virülens faktörlerin fenotipik ve genotipik yöntemler kullanılarak araştırılmasıdır. YSAD enterokok izolatlarında α-hemolitik (48.15 %), γ-hemolitik (46.30 %), ve β-hemolitik (5.55 %) aktivite fenotipik olarak belirlendi. Jelatinaz aktivitesi yalnız E. faecalis RG22.4, RG26.1 ve RG26.2 suşlarında tespit edildi. Polimeraz zincir reaksiyonu (PZR) ile E. faecium RS32.2 hariç YSAD enterokok izolatlarında en az bir virülens genin varlığı belirlendi. YSAD enterokok izolatlarında en sık görülen genlerin ccf (% 88.89), efaAfs (% 85.19), acm (% 77.78), gelE (% 59.2), cpd (% 51.85) ve espfs (% 50) olduğu tespit edildi. Fenotipik ve genotipik testler sonucu, 30 YSAD enterokok izolatında sessiz gelE geni bulundu. Peynirden izole edilen YSAD enterokok suşlarında yüksek sıklıkla virülens faktör genlerinin tespit edilmesi tüketici sağlığı için endişe uyandırıcıdır.

show abstract

Enterococcal Infections in Adults

Cited by 4 publications

References 58 publications

Impact on Public Health of the Spread of High-Level Resistance to Gentamicin and Vancomycin in Enterococci

Impact on Public Health of the Spread of High-Level Resistance to Gentamicin and Vancomycin in Enterococci

Vancomycin drug resistance, an emerging threat to animal and public health

Investigation of Virulence Factors Using Phenotypic and Genotypic Methods in High-Level Aminoglycoside Resistant Enterococci Isolated From Cheese

Contact Info

Product

Resources

About