Enterohepatic Circulation of C14-Labeled Bile Salts in Disorders of the Distal Small Bowel

Heaton, K W; Austad, W. I.; Lack, Leon; Tyor, Malcolm P.

doi:10.1016/s0016-5085(19)34093-4

Cited by 89 publications

(8 citation statements)

References 21 publications

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“…Bile salt metabolism in patients after various degrees of ileal resection has been studied (Hofmann & Grundy, 1965;Meihoff & Kern, 1968;Van Deest et al, 1968;Heaton, Austad, Lack & Tyor, 1968;Stanley & Nemchausky, 1967;McLeod & Wiggins, 1968;Abaurre, Gordon, Mann & Kern, 1969) but in all of these studies the colon has been in situ and the part played by colonic metabolism of bile salts has been difficult to assess. We have selected patients in whom ileostomy, after total proctocolectomy for ulcerative colitis, accompanied ileal resection.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ileal Resection on Bile Salt Metabolism in Patients with Ileostomy following Proctocolectomy

et al. 1971

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1. Bile salt metabolism has been studied in seven patients with ileostomy following total proctocolectomy; three of these patients also had various degrees of ileal resection. 2. The half-life of the cholic acid pool was shortened in the patients with ileal resection. 3. Rates of bile acid synthesis were raised in two of the three patients with ileal resection. In the third, the rate was normal. 4. Four of the six patients had low bile acid concentrations in the duodenum after a fatty meal. 5. Deoxycholic acid could not be detected in the duodenum or ileal effluent of any of the patients.

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Section: Discussionmentioning

confidence: 99%

Effect of Ileal Resection on Bile Salt Metabolism in Patients with Ileostomy following Proctocolectomy

et al. 1971

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“…The methods used have previously been described in detail (Austad, Lack, and Tyor, 1967;Heaton, Austad, Lack, and Tyor, 1968). Studies were carried out over a period of five to six days.…”

Section: Methodsmentioning

confidence: 99%

The effect of cholecystectomy on bile salt metabolism

Pomare¹,

Heaton²

1973

Gut

185

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“…On four mornings during the subsequent four to seven days duodenal bile was aspirated and 3-5 ml retained for analysis. The method for separating taurocholic acid by thin-layer chromatography and measuring its rate of fall of specific activity in duodenal contents, and of calculating pool size and daily turnover, has previously been described (Austad, Lack, and Tyor, 1967;Heaton, Austad, Lack, and Tyor, 1968). The correlation coefficient (r), representing the goodness of fit of the regression line (log specific activity versus time), was calculated for each patient.…”

Section: Measurement Of Taurocholate Pool Size and Turnover And Of Tomentioning

confidence: 99%

The effect of coeliac disease upon bile salts

Low-Beer¹,

Heaton²,

Pomare³

et al. 1973

Gut

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SUMMARY The size and composition ofthe bile salt pool has been measured in patients with untreated coeliac disease and in control subjects. The total bile salt pool was markedly increased in coeliac patients, the average being 9.2 grams compared with 3.1 grams in controls. Taurocholate synthesis was normal, consistent with its enlarged pool and prolonged half-life. Half-life and pool size were significantly correlated. The composition of the bile salt pool was virtually identical in the two groups. Our findings suggest that as the enterohepatic circulation is slowed by gallbladder inertia, so hepatic surveillance of pool size is diminished.We have recently shown that in patients with untreated coeliac disease the gallbladder is relatively inert and the enterohepatic circulation of bile salts more sluggish than normal (Low-Beer, Heaton, Heaton, and Read, 1971). We attributed this to a failure of the damaged upper small intestinal mucosa to release cholecystokinin. This paper is concerned with the effect of the disease on the size of the bile salt pool, its composition, and its daily rate of turnover. Subjects and MethodsPatients with adult coeliac disease, in whom jejunal biopsy showed subtotal villous atrophy, and who were taking an unrestricted diet, volunteered to undertake these studies; they were compared with a group of age-matched volunteers with no history of gastrointestinal disease drawn from members of staff, hospital outpatients, and medical students. All analyses were performed on bile aspirated after an overnight fast through a tube in the duodenum. Bile flow was stimulated by an iv injection of 10-40 Ivy dog units of cholecystokinin. (Bruusgaard, 1970). The specificity of the salicylaldehyde method for measuring deoxycholic acid is shown in figure 1. In this experiment, the effect of increasing amounts of chenodeoxycholic acid on the absorbance at 700 ,u due to fixed amounts of glycodeoxycholic acid was measured. Chenodeoxycholic acid produced 3 % of the absorbance compared with equimolar amounts of glyco-PM

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Enterohepatic Circulation of C14-Labeled Bile Salts in Disorders of the Distal Small Bowel

Cited by 89 publications

References 21 publications

Effect of Ileal Resection on Bile Salt Metabolism in Patients with Ileostomy following Proctocolectomy

Effect of Ileal Resection on Bile Salt Metabolism in Patients with Ileostomy following Proctocolectomy

The effect of cholecystectomy on bile salt metabolism

The effect of coeliac disease upon bile salts

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