Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children

Abstract

The review analyzes mechanisms and concomitant factors in developing IgE-associated allergic diseases provoked by food allergens and discusses clinical symptoms and current approaches for the treatment of food allergies. The expediency of using enterosorbents in complex therapy of food allergies and skin and respiratory manifestations associated with gastroenterological disorders is substantiated. The review summarizes the experience of using enterosorbents in post-Soviet countries to detoxify the human body. In this regard, special attention is paid to the enterosorbent White Coal (Carbowhite) based on silicon dioxide produced by the Ukrainian company OmniFarma.

Enterosorption may contribute to the reactivation of anticancer immunity and be an effective approach to tumor growth control

“…Based on these data, the normalization of gut microbiota and body detoxification becomes of paramount importance in shaping an adequate immune response not only to tumor antigens but also to a broad spectrum of other harmful substances including pathogenic microflora and allergens ( 3 ). In this context, enterosorption may emerge as a crucial additional factor in restoring compromised immune competence ( Figures 1 , 2 ).…”

“…While enterosorbents have already proven to be effective in detoxification for dysbiosis, alcohol intoxication, industrial toxin poisonings, and food allergies ( 1 – 3 ), studies regarding their application in various forms of oncological diseases still are scarce and are limited to local preclinical investigations with use of carbon adsorption therapy for Lewis lung carcinoma, Geren’s carcinoma, radiation-induced breast cancer, and acute radiation sickness and iatrogenic leukopenia ( 4 – 7 ). These studies demonstrated the positive effects of enterosorption on the restoration of homeostasis, normalization of biochemical and hematological blood parameters, a significant reduction in the toxic load caused by the use of chemotherapy and radiation, as well as an increase in the survival rate of experimental animals.…”

“…Additionally, selective nonspecific absorption of pathogenic microflora and their toxic metabolites by enterosorbents may preserve cancer patients from the fatal infection process ( Figure 2 ). At this, the risks of side effects associated with enterosorbent use are minimal or absent when appropriate recommendations are followed ( 3 ).…”

“…Enterosorption is one of the safest and most effective methods for binding and excretion of various exogenic and endogenic toxins and metabolites from the body based on oral administration of an enterosorbent that can absorb toxic substances in the lumen of the gastrointestinal tract without entering into chemical reactions. Enterosorbents can provide body detoxification by several mechanisms - directly in the gut and by resorption from blood and lymph ( 1 – 3 ). Many studies show the high efficiency of enterosorption detoxification in the complex treatment of various diseases including cancer, allergy, dysbiosis, hepatobiliary toxicosis, and various systemic intoxications ( 1 – 7 ).…”

“…These complex effects of enterosorption may result in the reactivation of the immune system and increase anticancer immunity. Modified from Shichkin et al., 2023 ( 3 ); this is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).…”