Enterotoxigenicity and invasiveness of Salmonella species

Abstract

A large number of enterotoxigenic strain was encountered in a group 56 Salmonella cultures belonging to 8 species viz., S. alachua, S. anatum, S. dublin, S. Enteritidis, S. hindmarsh, S. newport, S. typhimurium, S. weltevreden, and 5 serotypes of S. arizona (16:z4:--; 48:1,v:z56; 53:z52:z53; 60:r:z; 60:i:z53). These cultures were isolated mainly from humans and animals suffering from gasteroenteritis. The enterotoxigenic (diarrhoeagenic) Salmonella cultures possess capacities for both skin permeation and epithelial penetration (invasiveness). Preliminary characterization revealed that Salmonella enterotoxin is a heat-labile protein of high molecular weight. It is suggested that enterotoxigenic and invasive properties play a vital role in the pathogenesis of Salmonella diarrhoea.

Multiple host defense defects in failure of C57BL/6 ep/ep (pale ear) mice to resolve visceral Leishmania donovani infection

“…The comparison with models for salmonellosis is further complicated by the observation that the mouse strain used can influence results obtained in the infant suckling mouse assay (42a). This may be the reason why studies using infant Swiss mice did not observe enteropathogenicity of S. typhimurium strains (20,34). Therefore, the use of BALB/c mice may be recommended for future studies using this animal model.…”

Short Communication

“…It is suggested that enterotoxigenic properties are vital for pathogenesis of Salmonella diarrhea. Vascular permeability reaction in rabbit skin has been shown to demonstrate enterotoxigenic potential of Salmonella by several workers (Kaura et al 1982;Chary et al, 1993). Culture filtrates of Salmonella have been shown to produce two skin permeability factors (PF).…”