Enterovirus A71 Infection

Wong, Kum Thong; Ong, Kien Chai; Couderc, Thérèse; Lecuit, Marc

doi:10.1002/9781119467748.ch22

Cited by 1 publication

(2 citation statements)

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“…Human enterovirus 71 (EV‐A71) belongs to Enterovirus A species within the genus Enterovirus (family Picornaviridae ). EV‐A71 mainly affects children and usually causes self‐limited infections, such as hand‐foot‐mouth disease, herpangina, pharyngitis, nonspecific febrile illness, viral exanthema, and enteritis 1,2 . However, EVs‐A71 can be particularly virulent, leading to mild central nervous system involvement, such as myoclonic jerk and aseptic meningitis, or severe complications, such as encephalitis, polio‐like syndrome, or encephalomyelitis 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Recently, EV‐A71 has caused particular public health concerns due to cyclic epidemics occurring every 2–3 years in the Asia‐Pacific region 4–6 . Meanwhile, EV‐A71 has continued to cause sporadic cases or limited clusters of cases in Europe and in North America 2 . Since 2014, accumulating neurological cases were reported in several European countries such as France, Spain, Denmark, and Germany 7 .…”

Section: Introductionmentioning

confidence: 99%

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Circulation of enterovirus A71 during 2019–2020, Marseille, France

Luciani

Morand

Zandotti

et al. 2021

Journal of Medical Virology

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Enteroviruses A71 (EVs‐A71) are known to cause serious neurological infections, especially in the pediatric population. We report here eight cases of EV‐A71 infection diagnosed in Marseille over the past 2 years (seven cases in 2019 and one case in 2020). Only children under 5 years of age were affected, including one case of acute flaccid paralysis. Viral RNA was detected by RT‐PCR in peripheral samples for all cases (feces and upper respiratory samples). Phylogenetic analyses based on VP1 and 2C3C coding regions revealed that all these cases of EV‐A71 infection were caused by viruses belonging to the subgenogroup C1 that currently circulates in Europe and that these viruses are genetically closed to other EVs‐A71 recently detected in European countries. These data therefore reinforce the usefulness of the enterovirus surveillance network and the need for systematic screening for EV‐A71 in case of an enteroviral infection. This study therefore suggests that the systematic screening for EV‐A71 in case of enteroviral infection could provide additional data for enterovirus surveillance networks.

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Section: Introductionmentioning

confidence: 99%