Enterovirus D68 in a 6-year-old acute flaccid myelitis case in China, 2018: a case report

Wang, Xiaoli; Zhang, Pengfei; Li, Jie; Chu, Yanhui; Zheng, Lei; Yang, Yang; Li, Fu; Cui, Shujuan; Huo, Da; Wang, Yu; Wang, Quanyi

doi:10.1186/s12879-020-4829-y

Cited by 7 publications

(13 citation statements)

References 13 publications

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“…Para su diagnóstico es necesario descartar VHS-1, VHS-2, HVH-6, VVZ, CMV, EBV y enterovirus (PCR en LCR), enfermedad de Lyme (serología en suero y, en caso de positividad, determinación del índice de producción intratecal), seroconversión de Mycoplasma pneumoniae; serologías en sangre y LCR para Treponema pallidum, y serologías para HIV (que se asocia característicamente a mielopatía crónica, por lo que una MT aguda en estos pacientes debe orientar a coinfección por VVZ, CMV, sífilis o tuberculosis). (7)(8)(9)(10)(11)(12)(13) No se ha podido establecer una relación causal inequívoca entre la vacuna de la gripe y la hepatitis B y MT post-vacunal. (7)(8)(9)(10)(11)(12)(13) La MT post-infecciosa se define por la evidencia serológica de infección en los días o la semana anteriores, por diferentes agentes (mononucleosis infecciosa, gripe, enterovirus, micoplasma, hepatitis A, B o C, SARS-CoV-2), asumiéndose un mecanismo inmunomediado más que acción directa del patógeno.…”

Section: Revisión De La Literaturaunclassified

“…(7)(8)(9)(10)(11)(12)(13) No se ha podido establecer una relación causal inequívoca entre la vacuna de la gripe y la hepatitis B y MT post-vacunal. (7)(8)(9)(10)(11)(12)(13) La MT post-infecciosa se define por la evidencia serológica de infección en los días o la semana anteriores, por diferentes agentes (mononucleosis infecciosa, gripe, enterovirus, micoplasma, hepatitis A, B o C, SARS-CoV-2), asumiéndose un mecanismo inmunomediado más que acción directa del patógeno. (7)(8)(9)(10)(11)(12)(13) Entre las enfermedades sistémicas, el Síndrome de Sjögren puede manifestarse como una MT aguda parcial.…”

Section: Revisión De La Literaturaunclassified

“…(7)(8)(9)(10)(11)(12)(13) La MT post-infecciosa se define por la evidencia serológica de infección en los días o la semana anteriores, por diferentes agentes (mononucleosis infecciosa, gripe, enterovirus, micoplasma, hepatitis A, B o C, SARS-CoV-2), asumiéndose un mecanismo inmunomediado más que acción directa del patógeno. (7)(8)(9)(10)(11)(12)(13) Entre las enfermedades sistémicas, el Síndrome de Sjögren puede manifestarse como una MT aguda parcial. El 2% de los pacientes con Lupus Eritematoso Sistémico (LES) presenta afección medular vasculítica o isquémica durante el transcurso de su enfermedad, pero la detección de anticuerpos anti-acuaporina 4 (IgG-NMO) indicará la coexistencia de una neuromielitis óptica (NMO).…”

Section: Revisión De La Literaturaunclassified

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Mielitis transversa post-infecciosa asociada a Síndrome de Froin. Presentación de un caso.

Marrero

Sánchez

2021

ArchPat

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La Mielitis transversa aguda es la inflamación aguda de uno o más segmentos medulares adyacentes, secundaria a esclerosis múltiple, infecciones, inflamación autoinmunitaria o post-infecciosa, vasculitis, fármacos. Provoca déficit motor y sensitivo bilateral, y de esfínteres por debajo del nivel de lesión. El diagnóstico suele ser realizado por resonancia magnética nuclear, estudio del líquido cefalorraquídeo y en estudios de la sangre. Los corticoides intravenosos, la plasmaféresis, las medidas sintomáticas y la corrección de la causa, constituyen su tratamiento. El síndrome de Froin consiste en xantocromía, elevación de proteínas e hipercoagulabilidad del LCR por bloqueo de su circulación a nivel medular, o a irritación meníngea. Se presenta el caso de un paciente con diagnóstico de mielitis transversa y síndrome de Froin. Se hace revisión breve de la literatura.

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Section: Revisión De La Literaturaunclassified

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Mielitis transversa post-infecciosa asociada a Síndrome de Froin. Presentación de un caso.

Marrero

Sánchez

2021

ArchPat

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“…EV-D68 infection was rst identi ed in Beijing, China, in 2006 [14]. Since then, more and more EV-D68-related illnesses had been reported in other regions of China, such as Shandong [15], Zhejiang [16], Shanghai [17], Jiangsu [18], Hong Kong [19] and Taiwan [20]. However, no vaccine or speci c therapy is yet available.…”

Section: Introductionmentioning

confidence: 99%

Serological Study of Neutralizing Antibodies Against Enterovirus D68 Among Healthy Population in Xiamen, China

Cheng¹,

Lin²,

Zhu³

et al. 2020

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Abstract Background: Enterovirus D68 (EV-D68) infections poses a serious public health threat, which caused outbreaks of severe respiratory illness and has been closely associated with "polio-like" central nervous system disease. The patterns of immune responses to EV-D68 have not been fully understood. This study was performed to investigate the level of neutralizing antibody against EV-D68 among the healthy population in Xiamen City.Methods: A total of 515 serum samples from healthy people were selected by stratified random sampling in Xiamen City in 2016, and the titer of neutralizing antibody against EV-D68 was detected by an efficient micro-neutralization assay.Results: The overall seroprevalence of neutralizing antibody against EV-D68 was 81.9%, and the overall geometric mean titers (GMT) was 248.0. The positive rates were 42.2%, 49.3%, 71.9%, 94.2% and 98.5%, respectively, in groups of <1, 1-3, 4-6, 7-19 and 20-39 years old, and were up to 100% in the 40-59 and ≥ 60 age groups. The GMTs in these seven groups were 1:39.8, 1:80.6, 1:133.2, 1:283.7, 1:253.3, 1:308.1 and 1:405.0, respectively. The seroprevalence and GMT of EV-D68 showed an increased trend with age, while gender and geographic area didn’t show significant impact.Conclusions: EV-D68 infection was prevalent in Xiamen City. Children are the high-risk groups for EV-D68-related illnesses, especially those aged ≤ 3 years. It is necessary to establish preventive measures and strengthened the surveillance on EV-D68 to prevent disease outbreaks.

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“…These may provide some hints for the reason of EV-D68 associated with neurological diseases.There was little data about the prevalence of EV-D68 in China after 2017. Notably, EV-D68 was detected from a case for the rst time with AFP in China in 2018 [21]. In this study, we explored EV-D68 infection in patients with acute lower respiratory tract infection (ALRTI) based on a multicenter study of a network monitoring viral pathogens of ALRTI from 7 hospitals of 6 provinces in China during 2017-2019.…”

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Enterovirus D68 infection in children with acute lower respiratory tract infection in China

Chen

et al. 2022

Preprint

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Background EV-D68 infection related acute flaccid paralysis (AFP) attracts much attention since the outbreak in the USA in 2014. Notably, EV-D68 was detected from a child with acute flaccid paralysis for the first time in China in 2018. Methods Based on a multicentre study monitoring viral pathogens of acute lower respiratory tract infection in children in China from May 2017 to December 2019, 10 EV-D68 positive specimens were detected from 3071 samples. Results These 10 patients presented with mild diseases and no neurological symptoms and signs. The phylogenetic analysis shows that all 10 obtained sequences belong to subclade B3 which circulates dominantly at present all over the world and shares high identity with strains related to AFP in the USA. Moreover, four EV-D68 strains are successfully isolated and it is worth noting that the isolate in this study is able to infect “neuronal-like” cell line SH-SY5Y which was used to identify the neurotropism of enteroviruses. Further, amino acid and nucleotide sites related to neurovirulence were analyzed, but these analysis results are not enough to explain the ability of our strains to infect SH-SY5Y cells. This suggests that the EV-D68 isolate in China has potential neuropathic capacity. Conclusions In conclusion, EV-D68 infection was detected in a small number of children with acute lower respiratory tract infections in China from 2017 to 2019. The genotype of EV-D68 in this study is B3, which has the ability to infect “neuronal-like” cell line SH-SY5Y.

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Enterovirus D68 in a 6-year-old acute flaccid myelitis case in China, 2018: a case report

Cited by 7 publications

References 13 publications

Mielitis transversa post-infecciosa asociada a Síndrome de Froin. Presentación de un caso.

Mielitis transversa post-infecciosa asociada a Síndrome de Froin. Presentación de un caso.

Serological Study of Neutralizing Antibodies Against Enterovirus D68 Among Healthy Population in Xiamen, China

Enterovirus D68 infection in children with acute lower respiratory tract infection in China

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